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Common Stock, Preferred Stock and Warrants - Additional Information (Detail) - USD ($)
 1 Months Ended 3 Months Ended 6 Months Ended
Aug. 06, 2020
Nov. 03, 2017
May 31, 2020
Aug. 31, 2019
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Aug. 12, 2019
Class Of Stock [Line Items]                    
Common stock, shares outstanding         114,756,092   114,756,092   110,190,000  
Issuance of common stock and preferred stock (in shares)       18,525,000            
Common stock, par value       $ 0.001 $ 0.001   $ 0.001   $ 0.001  
Preferred stock, par value         $ 0.001   $ 0.001   $ 0.001  
Net cash proceeds received             $ 28,156,000 $ 107,697,000    
Change in fair value of warrant liability         $ (2,097,000) $ 25,655,000 $ 23,455,000 $ 17,045,000    
Common Stock                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)           21,197,000 2,879,000 24,106,000    
Warrants                    
Class Of Stock [Line Items]                    
Warrants Called for purchase         5,091,000   5,091,000      
Fair value of derivative liability         $ 29,600,000   $ 29,600,000     $ 7,400,000
Warrants | Other Income, Net                    
Class Of Stock [Line Items]                    
Change in fair value of warrant liability         $ 2,100,000   $ 23,500,000      
Bain Life Sciences                    
Class Of Stock [Line Items]                    
Net cash proceeds received from issuance or sale of equity       $ 35,000,000.0            
Bain Life Sciences | Common Stock                    
Class Of Stock [Line Items]                    
Warrants Called for purchase         2,916,250   2,916,250      
Proceeds From Warrants Sale         11.8   11.8      
Bain Capital Life Sciences Fund, L.P                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)       6,826,266            
Number of common stock allowed to purchase       2,645,566            
Net cash proceeds received from issuance or sale of equity       $ 31,700,000            
Bain Capital Life Sciences Fund, L.P | Common Stock                    
Class Of Stock [Line Items]                    
Warrants Called for purchase         2,645,566   2,645,566      
BCIP Life Sciences Associates, L.P                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)       698,734            
Number of common stock allowed to purchase       270,684            
Net cash proceeds received from issuance or sale of equity       $ 3,200,000            
BCIP Life Sciences Associates, L.P | Common Stock                    
Class Of Stock [Line Items]                    
Warrants Called for purchase         270,684   270,684      
Offering                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)     2,100,000              
Common stock, par value     $ 0.001              
Number of common stock allowed to purchase       0.25            
Combined price of common stock and warrant       $ 3.00            
Net cash proceeds received from issuance or sale of equity     $ 75,400,000 $ 65,600,000            
Payment of issuance costs       $ 4,500,000            
Price of common stock     $ 5.00              
Offering | Bain Capital Life Sciences Fund, L.P                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)     1,000,000              
2017 ATM Agreement                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)             2,878,567      
Net cash proceeds received             $ 28,200,000      
Remaining proceeds from common stock, under sales agreement             $ 120,500,000      
Series B Convertible Preferred Stock                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)       4,840            
Preferred stock, par value       $ 0.001            
Preferred stock, shares outstanding         4,140   4,140   4,000  
Preferred stock deemed dividend             $ 3,300,000      
Series B Convertible Preferred Stock | Common Stock                    
Class Of Stock [Line Items]                    
Number of common stock allowed to purchase         1,000   1,000      
Series B Convertible Preferred Stock | Bain Capital Life Sciences Fund, L.P                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)       3,756            
Series B Convertible Preferred Stock | BCIP Life Sciences Associates, L.P                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)       384            
Series B Convertible Preferred Stock | Offering                    
Class Of Stock [Line Items]                    
Number of common stock allowed to purchase       250            
Combined price of preferred stock and warrant       $ 3,000            
Maximum                    
Class Of Stock [Line Items]                    
Common stock sales agreement aggregate sales proceeds $ 150,000,000                  
Maximum | Warrants                    
Class Of Stock [Line Items]                    
Percentage of common stock held not to exceed for warrant exercises             19.99%      
Maximum | Offering                    
Class Of Stock [Line Items]                    
Issuance of common stock and preferred stock (in shares)     16,100,000              
Warrant issued       5,841,250            
Maximum | 2017 ATM Agreement                    
Class Of Stock [Line Items]                    
Common stock sales agreement aggregate sales proceeds   $ 150,000,000                
Commission on gross sales proceeds of common stock   3.00%                
Maximum | Series B Convertible Preferred Stock                    
Class Of Stock [Line Items]                    
Percentage of common stock held not to exceed for warrant exercises             19.99%      
Minimum | Warrants                    
Class Of Stock [Line Items]                    
Percentage of common stock to be held for exercise of warrants             4.99%      
Minimum | Series B Convertible Preferred Stock                    
Class Of Stock [Line Items]                    
Percentage of common stock to be held for conversion             4.99%