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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Preferred Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning Balances at Dec. 31, 2019 $ 8,290 $ 84   $ 1,229,417 $ (2,387) $ (1,218,824)
Beginning Balances (in shares) at Dec. 31, 2019   83,871 5      
Conversion of preferred stock 1 $ 1        
Conversion of preferred stock, shares   700        
Conversion of preferred stock, shares     1      
Issuance of common stock upon exercise of stock options and restricted stock awards, net 224 $ 1   223    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   1,192        
Issuance of common stock under Employee Stock Purchase Plan 672     672    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   195        
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement 108,537 $ 24   108,513    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   24,215        
Stock compensation expense 9,968     9,968    
Total other comprehensive income (Loss) 1,365       1,365  
Net (loss) income (59,773)         (59,773)
Ending Balances at Sep. 30, 2020 69,284 $ 110   1,348,793 (1,022) (1,278,597)
Ending Balances (in shares) at Sep. 30, 2020   110,173 4      
Beginning Balances at Jun. 30, 2020 58,295 $ 109   1,343,279 (2,095) (1,282,998)
Beginning Balances (in shares) at Jun. 30, 2020   109,503 4      
Issuance of common stock upon exercise of stock options and restricted stock awards, net 213 $ 1   212    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   457        
Issuance of common stock under Employee Stock Purchase Plan 361     361    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   104        
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement 839     839    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   109        
Stock compensation expense 4,102     4,102    
Total other comprehensive income (Loss) 1,073       1,073  
Net (loss) income 4,401         4,401
Ending Balances at Sep. 30, 2020 69,284 $ 110   1,348,793 (1,022) (1,278,597)
Ending Balances (in shares) at Sep. 30, 2020   110,173 4      
Beginning Balances at Dec. 31, 2020 58,693 $ 110   1,352,374 273 (1,294,064)
Beginning Balances (in shares) at Dec. 31, 2020   110,190 4      
Conversion of preferred stock 0 $ 4   (4)    
Conversion of preferred stock, shares   4,140        
Conversion of preferred stock, shares     4      
Issuance of common stock upon exercise of stock options and restricted stock awards, net 5,317 $ 2   5,315    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   1,415        
Exercise of warrants 11,553 $ 1   11,552    
Exercise of warrants, shares   946        
Issuance of common stock under Employee Stock Purchase Plan 841     841    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   217        
Issuance of common stock, net of issuance costs, in conjunction with an underwritten public offering and an At Market Sales Agreement 28,156 $ 3   28,153    
Issuance of common stock, net of issuance costs, in conjunction with an At Market Sales Agreement (in shares)   2,879        
Issuance of capped call options (27,240)     (27,240)    
Stock compensation expense 15,123     15,123    
Total other comprehensive income (Loss) (1,801)       (1,801)  
Net (loss) income (23,066)         (23,066)
Ending Balances at Sep. 30, 2021 67,576 $ 120   1,386,114 (1,528) (1,317,130)
Ending Balances (in shares) at Sep. 30, 2021   119,787        
Beginning Balances at Jun. 30, 2021 83,380 $ 114   1,372,679 (713) (1,288,700)
Beginning Balances (in shares) at Jun. 30, 2021   114,756 4      
Conversion of preferred stock 0 $ 4   (4)    
Conversion of preferred stock, shares   4,140        
Conversion of preferred stock, shares     4      
Issuance of common stock upon exercise of stock options and restricted stock awards, net 3,982 $ 2   3,980    
Issuance of common upon exercise of stock options and restricted stock awards, net (in shares)   582        
Exercise of warrants 3,625     3,625    
Exercise of warrants, shares   196        
Issuance of common stock under Employee Stock Purchase Plan 458     458    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   113        
Stock compensation expense 5,376     5,376    
Total other comprehensive income (Loss) (815)       (815)  
Net (loss) income (28,430)         (28,430)
Ending Balances at Sep. 30, 2021 $ 67,576 $ 120   $ 1,386,114 $ (1,528) $ (1,317,130)
Ending Balances (in shares) at Sep. 30, 2021   119,787