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Commitments and Contingencies - Additional Information (Detail)
€ in Millions
 1 Months Ended 12 Months Ended
Sep. 17, 2018
USD ($)
ft²
Sep. 30, 2021
USD ($)
Aug. 31, 2020
USD ($)
Jul. 31, 2019
USD ($)
ft²
Nov. 30, 2009
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2021
EUR (€)
May 31, 2021
USD ($)
Dec. 31, 2020
EUR (€)
Mar. 29, 2019
USD ($)
Feb. 20, 2018
USD ($)
Dec. 31, 2004
EUR (€)
Loss Contingencies [Line Items]                            
Tenant improvement allowance           $ 1,137,000 $ 6,999,000            
Sublease income           7,735,000 7,706,000 2,619,000            
Cash paid for amounts included in the measurement of operating lease liabilities           7,000,000.0 6,900,000              
Principal amount           $ 225,500,000       $ 225,500,000        
Debt maturity date           May 15, 2026                
Non-cancelable purchase and other commitments           $ 98,726,000                
Liability under agreement           $ 816,872,000 294,579,000              
Incremental borrowing rate           10.10%                
Long-term debt, net of debt discount           $ 5,010,000 1,094,000              
Gain on sale of assets           1,000,000 6,851,000 0            
Selling, general and administrative           100,156,000 79,256,000 74,986,000            
2.50% Convertible Senior Notes Due 2026                            
Loss Contingencies [Line Items]                            
Principal amount           $ 225,500,000                
Debt maturity date           May 15, 2026                
Long-term debt, net of debt discount           $ 5,000,000.0                
Asset Purchase Agreement                            
Loss Contingencies [Line Items]                            
Upfront payment             5,000,000              
Upfront payment receivable             4,000,000              
Additional milestone payments receivable             250,000,000              
Gain on sale of assets           $ 1,000,000 6,900,000              
Selling, general and administrative   $ 500,000 $ 2,500,000                      
Symphony Dynamo Holdings Llc                            
Loss Contingencies [Line Items]                            
License arrangement contingent consideration percentage         50.00%                  
License arrangement upfront payment         $ 50,000,000                  
Trisalus Life Sciences                            
Loss Contingencies [Line Items]                            
Payment Received For Pre Commercialization Milestone   $ 1,000,000                        
Deutsche Bank Securities                            
Loss Contingencies [Line Items]                            
Letter of credit pledged as security | €                           € 0.2
Collateralized certificate of deposit | €                 € 0.2   € 0.2      
CRG Servicing LLC                            
Loss Contingencies [Line Items]                            
Maximum borrowing capacity                         $ 175,000,000.0  
Current borrowing capacity                       $ 75,000,000.0 $ 100,000,000.0  
Debt maturity date           Dec. 31, 2023                
Emeryville, California (Premises) | Horton Street Sublease                            
Loss Contingencies [Line Items]                            
Lease area | ft² 75,662     75,662                    
Base rent per square feet $ 4,750     $ 5,500                    
Lease expiration date       Mar. 31, 2031                    
Option to extend       The Subtenant has no option to extend the sublease term.                    
Existence of option to extend       false                    
Operations commencement date Apr. 01, 2019                          
Tenant improvement allowance $ 8,100,000                          
Initial lease term 12 years                          
Lease option to extend The Horton Street Master Lease has an initial term of 12 years, following the Commencement Date with an option to extend the lease for two successive five-year terms                          
Renewal term of lease 5 years                          
Emeryville, California (Premises) | Horton Street Sublease | Other Nonoperating Income (Expense)                            
Loss Contingencies [Line Items]                            
Sublease income           $ 7,700,000 $ 7,700,000 $ 2,600,000            
Powell Street Sublease | Emeryville, California (Premises)                            
Loss Contingencies [Line Items]                            
Lease area | ft²       23,976                    
Base rent per square feet       $ 3.90                    
Lease expiration date       Jun. 30, 2022                    
Option to extend           There is no option to extend the sublease term.                
Existence of option to extend             false              
Horton Street Master Lease                            
Loss Contingencies [Line Items]                            
Percentage of excess rent paid to landlord           50.00%     50.00%          
New Dusseldorf Lease | Germany                            
Loss Contingencies [Line Items]                            
Operations commencement date   Jan. 01, 2022                        
Initial lease term   10 years                        
Lease option to extend   The New Düsseldorf Lease has an initial term of 10 years, beginning on January 1, 2022, with an option to extend the lease for two successive five-year terms.                        
Renewal term of lease   5 years