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Revenue Recognition - Schedule of Revenues from Major Customers (Detail) - Product Concentration Risk [Member] - Revenue Benchmark [Member] | 3 Months Ended
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Mar. 31, 2022 | Mar. 31, 2021
Largest Customer | HEPLISAV-B |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 25.00% | 28.00%
Second Largest Customer | HEPLISAV-B |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 20.00% | 26.00%
Third Largest Customer | HEPLISAV-B |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 16.00% | 21.00%
Largest Collaboration Partner | CpG 1018 |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 74.00% | 87.00%
Second Largest Collaboration Partner | CpG 1018 |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 24.00% | 9.00%
Third largest collaboration partner | CpG 1018 |  |
Concentration Risk [Line Items] |  |
Percentage of product revenue | 2.00% | 2.00%

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