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Organization and Summary of Significant Accounting Policies - Additional Information (Detail)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
USD ($)
Segment
Mar. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
May 31, 2021
USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Number of operating segment | Segment 1      
Long-term debt, net of debt discount $ 4,741   $ 5,010  
Net income 32,859 $ 891    
Inventory reserve $ 0 0    
Maximum        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Expected period of payment to be received 1 year      
2.50% Convertible Senior Notes Due 2026        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Aggregate principal amount $ 225,500 $ 158,800   $ 200,000
Debt interest rate 2.50%     2.50%
Long-term debt, net of debt discount $ 4,700      
Debt maturity date May 15, 2026      
HEPLISAV-B        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Minimum age approved for vaccine prevention of infection caused 18 years