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Revenue Recognition - Schedule of Revenues from Major Customers (Detail) - Product Concentration Risk [Member] - Revenue Benchmark [Member]	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	25.00%	28.00%
Second Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	20.00%	26.00%
Third Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	16.00%	21.00%
Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	74.00%	87.00%
Second Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	24.00%	9.00%
Third largest collaboration partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	2.00%	2.00%

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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