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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Operating activities    
Net income $ 32,859 $ 891
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 985 1,106
Amortization of right-of-use assets and loss on disposal of property and equipment 743 653
(Accretion of discounts) amortization of premium on marketable securities (181) 221
Change in fair value of warrant liability (1,801) 25,552
Stock compensation expense 7,646 4,723
Non-cash interest expense 1,680 414
Changes in operating assets and liabilities:    
Accounts and other receivables, net (5,120) (61,333)
Inventories, net (17,703) (5,157)
Prepaid manufacturing 21,325 (3,219)
Prepaid expenses and other current assets (9,231) (171)
Other assets (49) (95)
Accounts payable 16,938 (295)
Cepi Accrual (21,478) 0
Lease liabilities (806) (751)
Deferred revenue (36,661) 78,340
Accrued liabilities and other liabilities (39,589) (2,847)
Net cash provided by (used in) operating activities (50,443) 38,032
Investing activities    
Purchases of marketable securities (250,375) (72,016)
Proceeds from maturities and redemptions of marketable securities 35,250 51,130
Purchases of property and equipment, net (1,358) (1,747)
Net cash used in investing activities (216,483) (22,633)
Financing activities    
Proceeds from issuance of common stock, net 0 28,156
Proceeds from warrants exercises 8,455 3,377
Proceeds from exercise of stock options and restricted stock awards, net 1,122 387
Proceeds from Employee Stock Purchase Plan 710 383
Net cash provided by financing activities 10,287 32,303
Effect of exchange rate changes on cash, cash equivalents and restricted cash (134) (731)
Net (decrease) increase in cash, cash equivalents and restricted cash (256,773) 46,971
Cash, cash equivalents and restricted cash at beginning of period 436,408 32,310
Cash, cash equivalents and restricted cash at end of period 179,635 79,281
Supplemental disclosure of cash flow information    
Cash paid during the period for income taxes 87 0
Cash paid during the period for interest 0 4,296
Non-cash investing and financing activities:    
Purchases of property and equipment, not yet paid 2,007 411
Right-of-use assets obtained in exchange of lease liabilities (modification) $ 1,173 $ 0