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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
May 31, 2021
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Long-term debt, net of debt discount $ 4,470,000   $ 4,470,000   $ 5,010,000  
Net income 128,755,000 $ 4,473,000 $ 161,614,000 $ 5,364,000    
Maximum            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Expected period of payment to be received     1 year      
2.50% Convertible Senior Notes Due 2026            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Aggregate principal amount $ 225,500,000   $ 225,500,000     $ 200,000,000.0
Debt interest rate 2.50%   2.50%     2.50%
Long-term debt, net of debt discount $ 4,500,000   $ 4,500,000      
Debt maturity date     May 15, 2026      
HEPLISAV-B            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Minimum age approved for vaccine prevention of infection caused     18 years      
Increase in revenue adjustment 700,000   $ 700,000      
Inventory reserve 0 0 0 0    
CpG 1018            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Inventory reserve $ 0 $ 0 $ 0 $ 0