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Revenue Recognition - Summary of Disaggregation of Revenues (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Disaggregation Of Revenue [Line Items]        
Total revenues $ 256,464 $ 52,767 $ 370,456 $ 136,102
UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 32,822 13,688 55,238 22,251
Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 223,642 39,079 315,218 113,851
HEPLISAV-B        
Disaggregation Of Revenue [Line Items]        
Total revenues 32,680 13,688 53,490 21,991
HEPLISAV-B | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 31,739 13,688 52,549 21,991
HEPLISAV-B | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 941 0 941 0
CpG 1018        
Disaggregation Of Revenue [Line Items]        
Total revenues 222,640 38,989 314,157 113,571
CpG 1018 | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 0 0 0 0
CpG 1018 | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 222,640 38,989 314,157 113,571
Product        
Disaggregation Of Revenue [Line Items]        
Total revenues 255,320 52,677 367,647 135,562
Product | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 31,739 13,688 52,549 21,991
Product | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 223,581 38,989 315,098 113,571
Other Revenue        
Disaggregation Of Revenue [Line Items]        
Total revenues 1,144 90 2,809 540
Other Revenue | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 1,083 0 2,689 260
Other Revenue | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues $ 61 $ 90 $ 120 $ 280