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Inventories, Net - Additional Information (Detail) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2022
Dec. 31, 2021
Inventory [Line Items]    
Prepaid manufacturing $ 12,727 $ 159,655
Provision for write down of inventory to cost of sales - product 14,500  
Finished goods 52,537 19,950
HEPLISAV-B    
Inventory [Line Items]    
Finished goods inventory 10,300 18,600
CpG 1018 Adjuvant Inventory    
Inventory [Line Items]    
Prepaid manufacturing 12,700 159,700
Finished goods inventory $ 42,200 $ 1,300