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Revenue Recognition - Summary of Disaggregation of Revenues (Detail) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Disaggregation Of Revenue [Line Items]        
Total revenues $ 167,735 $ 108,270 $ 538,191 $ 244,372
UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 41,385 23,907 96,623 46,158
Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 126,350 84,363 441,568 198,214
HEPLISAV-B        
Disaggregation Of Revenue [Line Items]        
Total revenues 37,508 22,707 90,998 44,698
HEPLISAV-B | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 37,508 22,707 90,057 44,698
HEPLISAV-B | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 0 0 941 0
CpG 1018 adjuvant        
Disaggregation Of Revenue [Line Items]        
Total revenues 440,464 197,860 126,307 84,289
CpG 1018 adjuvant | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 0 0 0 0
CpG 1018 adjuvant | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 440,464 197,860 126,307 84,289
Product        
Disaggregation Of Revenue [Line Items]        
Total revenues 163,815 106,996 531,462 242,558
Product | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 37,508 22,707 90,057 44,698
Product | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues 126,307 84,289 441,405 197,860
Other Revenue        
Disaggregation Of Revenue [Line Items]        
Total revenues 3,920 1,274 6,729 1,814
Other Revenue | UNITED STATES        
Disaggregation Of Revenue [Line Items]        
Total revenues 3,877 1,200 6,566 1,460
Other Revenue | Non-US        
Disaggregation Of Revenue [Line Items]        
Total revenues $ 43 $ 74 $ 163 $ 354