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Revenue Recognition - Schedule of Revenues from Major Customers (Detail) - Product Concentration Risk [Member] - Revenue Benchmark [Member]	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	23.00%	22.00%	20.00%	21.00%
Second Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	19.00%	20.00%	18.00%	21.00%
Third Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	18.00%	19.00%	17.00%	18.00%
Largest Collaboration Partner | CpG 1018 adjuvant
Concentration Risk [Line Items]
Percentage of product revenue	69.00%	62.00%	46.00%	45.00%
Second Largest Collaboration Partner | CpG 1018 adjuvant
Concentration Risk [Line Items]
Percentage of product revenue	22.00%	30.00%	33.00%	29.00%
Third largest collaboration partner | CpG 1018 adjuvant
Concentration Risk [Line Items]
Percentage of product revenue	9.00%	8.00%	15.00%	13.00%

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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