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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Operating activities    
Net income (loss) $ 225,423 $ (23,066)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Depreciation and amortization 2,975 3,280
Amortization of right-of-use assets and loss on disposal of property and equipment 2,244 2,013
Amortization of premium (accretion of discounts) on marketable securities (1,969) 442
Loss on debt extinguishment 0 5,232
Change in fair value of warrant liability (1,801) 68,576
Stock compensation expense 24,188 15,123
Non-cash interest expense 2,222 2,546
Inventory write-off 14,485 0
Gain on sale of assets (1,000) (1,000)
Changes in operating assets and liabilities:    
Accounts and other receivables, net 698 (177,701)
Inventories, net (55,759) (3,608)
Prepaid manufacturing 146,928 (80,340)
Prepaid expenses and other current assets (26,240) (51,887)
Other assets 61 (50)
Accounts payable 301 (545)
Lease liabilities (2,366) (2,416)
Deferred revenue (262,469) 320,376
Long Term Deferred Revenue 0 67,969
Accrued liabilities and other liabilities (19,043) 70,087
CEPI accrual (Note 6) (21,110) 0
Net cash provided by (used in) operating activities 27,768 215,031
Investing activities    
Purchases of marketable securities (514,676) (164,927)
Proceeds from maturities and redemptions of marketable securities 236,200 129,655
Purchases of property and equipment, net (5,552) (6,441)
Proceeds from sale of assets, net of transaction costs 1,000 1,000
Net cash used in investing activities (283,028) (40,713)
Financing activities    
Proceeds from issuance of common stock, net 0 28,156
Proceeds from issuance of Convertible Notes, net 0 219,822
Purchases of capped call options 0 (27,240)
Repayment of long-term debt 0 (190,194)
Proceeds from warrants exercised 8,455 4,258
Proceeds from exercise of stock options and restricted stock awards, net 9,487 5,317
Proceeds from Employee Stock Purchase Plan 1,430 841
Net cash provided by financing activities 19,372 40,960
Effect of exchange rate changes on cash, cash equivalents and restricted cash (1,755) (1,013)
Net (decrease) increase in cash, cash equivalents and restricted cash (237,643) 214,265
Cash, cash equivalents and restricted cash at beginning of period 436,408 32,310
Cash, cash equivalents and restricted cash at end of period 198,765 246,575
Supplemental disclosure of cash flow information    
Cash paid during the period for income taxes 788 0
Cash paid during the period for interest 2,819 6,965
Non-cash investing and financing activities:    
Purchases of property and equipment, not yet paid 973 1,561
Right-of-use assets obtained in exchange of lease liabilities 2,475 0
Remeasurement of operating lease right-of-use assets for lease modification $ 0 $ 2,468