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Revenue Recognition - Schedule of Revenues from Major Customers (Details) - Revenue Benchmark [Member] - Product Concentration Risk [Member] | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Largest Customer | HEPLISAV-B |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 21.00% | 21.00% | 21.00%
Second Largest Customer | HEPLISAV-B |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 17.00% | 19.00% | 20.00%
Third Largest Customer | HEPLISAV-B |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 16.00% | 19.00% | 20.00%
Largest Collaboration Partner | CpG 1018 |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 49.00% | 49.00% | 62.00%
Second Largest Collaboration Partner | CpG 1018 |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 35.00% | 24.00% | 36.00%
Third Largest Customer | CpG 1018 |  |  |
Concentration Risk [Line Items] |  |  |
Percentage of product revenue | 12.00% | 19.00% | 2.00%

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