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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 1 Months Ended 12 Months Ended
Aug. 31, 2020
USD ($)
Jul. 31, 2019
Nov. 30, 2009
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2022
EUR (€)
May 31, 2021
USD ($)
Mar. 29, 2019
USD ($)
Feb. 20, 2018
USD ($)
Dec. 31, 2004
EUR (€)
Loss Contingencies [Line Items]                      
Lease expiration date       Mar. 31, 2031              
Sublease income       $ 7,685 $ 7,735 $ 7,706          
Cash paid for amounts included in the measurement of operating lease liabilities       6,800 7,000 6,900          
Long-term debt, net of debt discount       $ 3,922 5,010            
Option to extend       The subtenant has no option to extend the sublease term.              
Tenant improvement allowance       $ 0 0 (1,137)          
Percentage of excess rent paid to landlord       50.00%     50.00%        
Non-cancelable purchase and other commitments       $ 43,408              
Liability under agreement       404,837 816,872            
Gain on sale of assets       1,000 1,000 6,851          
Selling, general and administrative       131,408 100,156 $ 79,256          
Current liabilities       150,074 556,402            
2.50% Convertible Senior Notes Due 2026                      
Loss Contingencies [Line Items]                      
Principal amount       225,500       $ 200,000      
Long-term debt, net of debt discount       $ 3,900              
Debt maturity date       May 15, 2026              
Asset Purchase Agreement                      
Loss Contingencies [Line Items]                      
Current liabilities       $ 0              
Symphony Dynamo Holdings Llc                      
Loss Contingencies [Line Items]                      
License arrangement contingent consideration percentage     50.00%                
License arrangement upfront payment     $ 50,000                
Trisalus Life Sciences                      
Loss Contingencies [Line Items]                      
Payment to holdings $ 2,500                    
Payment received for pre-commercialization milestone       1,000 1,000            
Trisalus Life Sciences | Asset Purchase Agreement                      
Loss Contingencies [Line Items]                      
Payment made for pre-commercialization milestone       $ 500 $ 500            
Deutsche Bank Securities                      
Loss Contingencies [Line Items]                      
Financial instruments owned at fair value | €             € 0.2        
Deutsche Bank Securities | Letter of Credit                      
Loss Contingencies [Line Items]                      
Financial instruments owned at fair value | €                     € 0.2
CRG Servicing LLC                      
Loss Contingencies [Line Items]                      
Debt maturity date       Dec. 31, 2023              
Maximum borrowing capacity                   $ 175,000  
Current borrowing capacity                 $ 75,000 $ 100,000  
Emeryville, California (Premises)                      
Loss Contingencies [Line Items]                      
Existence of option to extend   false                  
Emeryville, California and Dusseldorf, Germany                      
Loss Contingencies [Line Items]                      
Lease option to extend       Certain of these leases also include renewal options at our election to renew or extend the lease for two successive five-year terms              
Emeryville, California and Dusseldorf, Germany | Maximum                      
Loss Contingencies [Line Items]                      
Lease term       12 years     12 years        
Emeryville, California and Dusseldorf, Germany | Minimum                      
Loss Contingencies [Line Items]                      
Lease term       3 years     3 years        
Powell Street Sublease | Emeryville, California (Premises)                      
Loss Contingencies [Line Items]                      
Existence of option to extend           false