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Revenue Recognition - Schedule of Revenues from Major Customers (Details) - Revenue Benchmark [Member] - Product Concentration Risk [Member]	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	21.00%	21.00%	21.00%
Second Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	17.00%	19.00%	20.00%
Third Largest Customer | HEPLISAV-B
Concentration Risk [Line Items]
Percentage of product revenue	16.00%	19.00%	20.00%
Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	49.00%	49.00%	62.00%
Second Largest Collaboration Partner | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	35.00%	24.00%	36.00%
Third Largest Customer | CpG 1018
Concentration Risk [Line Items]
Percentage of product revenue	12.00%	19.00%	2.00%

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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