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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended |  |
--- | --- | --- | ---
Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | May 31, 2021
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |
Long-term debt, net of debt discount | $ 3,645 |  | $ 3,922 |
Net (loss) income | (24,332) | $ 32,859 |  |
2.50% Convertible Senior Notes Due 2026 |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |
Aggregate principal amount | 225,500 |  |  | $ 200,000
Debt interest rate |  |  |  | 2.50%
Long-term debt, net of debt discount | $ 3,600 |  |  |
Debt maturity date | May 15, 2026 |  |  |
HEPLISAV-B |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |
Minimum age approved for vaccine prevention of infection caused | 18 years |  |  |

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