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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
May 31, 2021
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Long-term debt, net of debt discount $ 3,645   $ 3,922  
Net (loss) income (24,332) $ 32,859    
2.50% Convertible Senior Notes Due 2026        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Aggregate principal amount 225,500     $ 200,000
Debt interest rate       2.50%
Long-term debt, net of debt discount $ 3,600      
Debt maturity date May 15, 2026      
HEPLISAV-B        
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]        
Minimum age approved for vaccine prevention of infection caused 18 years