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Commitments and Contingencies - Additional Information (Detail)
€ in Millions
 1 Months Ended 3 Months Ended
May 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
Nov. 30, 2009
USD ($)
Mar. 31, 2023
USD ($)
Mar. 31, 2022
USD ($)
Dec. 31, 2023
Mar. 31, 2023
EUR (€)
Dec. 31, 2022
USD ($)
May 31, 2021
USD ($)
Dec. 31, 2004
EUR (€)
Loss Contingencies [Line Items]                    
Lease expiration date       Mar. 31, 2031            
Option to extend       The subtenant has no option to extend the sublease term            
Sublease income       $ 1,598,000 $ 1,609,000          
Percentage of excess rent paid to landlord       50.00%     50.00%      
Cash paid for amounts included in the measurement of operating lease liabilities       $ 1,700,000 1,700,000          
Long-term debt, net of debt discount       3,645,000       $ 3,922,000    
Selling, general and administrative       36,543,000 $ 32,172,000          
Liabilities, Current       91,515,000       150,074,000    
HEPLISAV-B                    
Loss Contingencies [Line Items]                    
Purchase Obligation, Total       40,800,000       43,400,000    
Non-cancelable purchase and other commitments       40,800,000       $ 43,400,000    
Asset Purchase Agreement                    
Loss Contingencies [Line Items]                    
Liabilities, Current       0            
Symphony Dynamo Holdings LLC                    
Loss Contingencies [Line Items]                    
License arrangement contingent consideration percentage     50.00%              
License Arrangement Contingent Payment To Acquire License     $ 50,000,000              
License arrangement upfront payment     $ 50,000,000              
TriSalus                    
Loss Contingencies [Line Items]                    
Payment to holdings       2,500,000            
Payment received for Pre-commercialization milestone $ 1,000,000.0 $ 1,000,000.0                
TriSalus | Asset Purchase Agreement                    
Loss Contingencies [Line Items]                    
Payment made for Pre-commercialization milestone $ 500 $ 500                
Deutsche Bank Securities                    
Loss Contingencies [Line Items]                    
Financial Instruments, Owned, at Fair Value | €             € 0.2      
Deutsche Bank Securities | Letter of Credit [Member]                    
Loss Contingencies [Line Items]                    
Financial Instruments, Owned, at Fair Value | €                   € 0.2
2.50% Convertible Senior Notes Due 2026                    
Loss Contingencies [Line Items]                    
Aggregate principal amount       225,500,000         $ 200,000,000.0  
Long-term debt, net of debt discount       $ 3,600,000            
Debt maturity date       May 15, 2026            
Emeryville, California (Premises)                    
Loss Contingencies [Line Items]                    
Lease option to extend       Certain of these leases also include options to renew or extend the lease for two successive five-year terms            
Maximum [Member] | Emeryville, California (Premises)                    
Loss Contingencies [Line Items]                    
lease term           12 years        
Minimum [Member] | Emeryville, California (Premises)                    
Loss Contingencies [Line Items]                    
lease term       3 years     3 years