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Revenue Recognition - Summary of Disaggregation of Revenues (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Disaggregation Of Revenue [Line Items]    
Total revenues $ 46,925 $ 113,992
UNITED STATES    
Disaggregation Of Revenue [Line Items]    
Total revenues 46,925 22,416
Non-US    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 91,576
HEPLISAV-B    
Disaggregation Of Revenue [Line Items]    
Total revenues 43,451 20,810
HEPLISAV-B | UNITED STATES    
Disaggregation Of Revenue [Line Items]    
Total revenues 43,451 20,810
HEPLISAV-B | Non-US    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 0
CpG 1018 adjuvant    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 91,517
CpG 1018 adjuvant | UNITED STATES    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 0
CpG 1018 adjuvant | Non-US    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 91,517
Product    
Disaggregation Of Revenue [Line Items]    
Total revenues 43,451 112,327
Product | UNITED STATES    
Disaggregation Of Revenue [Line Items]    
Total revenues 43,451 20,810
Product | Non-US    
Disaggregation Of Revenue [Line Items]    
Total revenues 0 91,517
Other Revenue    
Disaggregation Of Revenue [Line Items]    
Total revenues 3,474 1,665
Other Revenue | UNITED STATES    
Disaggregation Of Revenue [Line Items]    
Total revenues 3,474 1,606
Other Revenue | Non-US    
Disaggregation Of Revenue [Line Items]    
Total revenues $ 0 $ 59