<?xml version="1.0" encoding="US-ASCII"?>
<!-- DFIN New ActiveDisclosure (SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date :2023-11-02T02:06:46.5891+00:00 -->
<!-- Copyright (c) 2023 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
<xsd:schema targetNamespace="http://www.dynavax.com/20230930" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:country="http://xbrl.sec.gov/country/2023" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2023" xmlns:dvax="http://www.dynavax.com/20230930" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:srt="http://fasb.org/srt/2023" xmlns:stpr="http://xbrl.sec.gov/stpr/2023" xmlns:us-gaap="http://fasb.org/us-gaap/2023" xmlns:xlink="http://www.w3.org/1999/xlink">
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd" namespace="http://xbrl.sec.gov/dei/2023"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-sub-2023.xsd" namespace="http://xbrl.sec.gov/ecd-sub/2023"/>
  <xsd:import schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" namespace="http://www.xbrl.org/dtr/type/2022-03-31"/>
  <xsd:import schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd" namespace="http://fasb.org/us-gaap/2023"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd" namespace="http://xbrl.sec.gov/country/2023"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd" namespace="http://xbrl.sec.gov/stpr/2023"/>
  <xsd:import schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd" namespace="http://fasb.org/srt/2023"/>
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dvax-20230930_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Labels link" xlink:type="simple"/>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dvax-20230930_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation link" xlink:type="simple"/>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dvax-20230930_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition link" xlink:type="simple"/>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dvax-20230930_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:title="Calculation link" xlink:type="simple"/>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DocumentDocumentAndEntityInformation" id="Role_DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheets" id="Role_StatementCondensedConsolidatedBalanceSheets">
        <link:definition>100010 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail2" id="DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail2">
        <link:definition>100020 - Disclosure - Commitments and Contingencies - Summary of Maturities of Sublease Income and Operating Lease Liabilities (Detail) 2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheetsParenthetical" id="Role_StatementCondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>100030 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureComputationOfBasicAndDilutedNetLossIncomePerShareDetail2" id="DisclosureComputationOfBasicAndDilutedNetLossIncomePerShareDetail2">
        <link:definition>100040 - Disclosure - Computation of Basic and Diluted Net (Loss) Income Per Share (Detail) 2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfOperationsUnaudited" id="Role_StatementCondensedConsolidatedStatementsOfOperationsUnaudited">
        <link:definition>100050 - Statement - Condensed Consolidated Statements of Operations (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/StatementCondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" id="StatementCondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited">
        <link:definition>100060 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail3" id="DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail3">
        <link:definition>100070 - Disclosure - Commitments and Contingencies - Summary of Maturities of Sublease Income and Operating Lease Liabilities (Detail) 3</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/StatementCondensedConsolidatedStatementsOfStockholdersEquityUnaudited" id="StatementCondensedConsolidatedStatementsOfStockholdersEquityUnaudited">
        <link:definition>100080 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited" id="Role_StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited">
        <link:definition>100090 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPolicies" id="Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPolicies">
        <link:definition>995455 - Disclosure - Organization and Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureFairValueMeasurements" id="Role_DisclosureFairValueMeasurements">
        <link:definition>995465 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecurities" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecurities">
        <link:definition>995475 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureInventories1" id="DisclosureInventories1">
        <link:definition>995485 - Disclosure - Inventories</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingencies" id="Role_DisclosureCommitmentsAndContingencies">
        <link:definition>995495 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCollaborativeResearchDevelopmentAndLicenseAgreements" id="Role_DisclosureCollaborativeResearchDevelopmentAndLicenseAgreements">
        <link:definition>995505 - Disclosure - Collaborative Research, Development and License Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureConvertibleNotes" id="Role_DisclosureConvertibleNotes">
        <link:definition>995515 - Disclosure - Convertible Notes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureRevenueRecognition" id="Role_DisclosureRevenueRecognition">
        <link:definition>995525 - Disclosure - Revenue Recognition</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureNetIncomePerShare" id="DisclosureNetIncomePerShare">
        <link:definition>995535 - Disclosure - Net Income Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCommonStockAndWarrants" id="DisclosureCommonStockAndWarrants">
        <link:definition>995545 - Disclosure - Common Stock and Warrants</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensation" id="Role_DisclosureEquityPlansAndStockBasedCompensation">
        <link:definition>995555 - Disclosure - Equity Plans and Stock-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>995565 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPoliciesPolicies" id="Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPoliciesPolicies">
        <link:definition>995575 - Disclosure - Organization and Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureFairValueMeasurementsTables" id="Role_DisclosureFairValueMeasurementsTables">
        <link:definition>995585 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesTables" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesTables">
        <link:definition>995595 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureInventoriesNetTables" id="Role_DisclosureInventoriesNetTables">
        <link:definition>995605 - Disclosure - Inventories, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesTables" id="Role_DisclosureCommitmentsAndContingenciesTables">
        <link:definition>995615 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureConvertibleNotesTables" id="Role_DisclosureConvertibleNotesTables">
        <link:definition>995625 - Disclosure - Convertible Notes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureRevenueRecognitionTables" id="Role_DisclosureRevenueRecognitionTables">
        <link:definition>995635 - Disclosure - Revenue Recognition (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureNetIncomePerShareTables" id="DisclosureNetIncomePerShareTables">
        <link:definition>995645 - Disclosure - Net Income Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCommonStockAndWarrantsTables" id="DisclosureCommonStockAndWarrantsTables">
        <link:definition>995655 - Disclosure - Common Stock and Warrants (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationTables" id="Role_DisclosureEquityPlansAndStockBasedCompensationTables">
        <link:definition>995665 - Disclosure - Equity Plans and Stock-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" id="Role_DisclosureOrganizationAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail">
        <link:definition>995675 - Disclosure - Organization and Summary of Significant Accounting Policies - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureFairValueMeasurementsAdditionalInformationDetail" id="Role_DisclosureFairValueMeasurementsAdditionalInformationDetail">
        <link:definition>995685 - Disclosure - Fair Value Measurements - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureFairValueHierarchyForFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetail" id="Role_DisclosureFairValueHierarchyForFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetail">
        <link:definition>995695 - Disclosure - Fair Value Hierarchy for Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureSummaryOfChangesInFairValueWarrantLiabilityDetail" id="Role_DisclosureSummaryOfChangesInFairValueWarrantLiabilityDetail">
        <link:definition>995705 - Disclosure - Summary of Changes in Fair Value Warrant liability (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesReconciliationOfCashCashEquivalentsAndRestrictedCashDetail" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesReconciliationOfCashCashEquivalentsAndRestrictedCashDetail">
        <link:definition>995715 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities - Reconciliation of Cash, Cash Equivalents and Restricted Cash (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesSummaryOfCashCashEquivalentsAndMarketableSecuritiesDetail" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesSummaryOfCashCashEquivalentsAndMarketableSecuritiesDetail">
        <link:definition>995725 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities - Summary of Cash, Cash Equivalents and Marketable Securities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesMaturitiesOfMarketableSecuritiesAvailableForSaleDetail" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesMaturitiesOfMarketableSecuritiesAvailableForSaleDetail">
        <link:definition>995735 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities - Maturities of Marketable Securities Available-for-Sale (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesAdditionalInformationDetail" id="Role_DisclosureCashCashEquivalentsRestrictedCashAndMarketableSecuritiesAdditionalInformationDetail">
        <link:definition>995745 - Disclosure - Cash, Cash Equivalents, Restricted Cash and Marketable Securities - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureInventoriesNetSummaryOfInventoriesDetail" id="Role_DisclosureInventoriesNetSummaryOfInventoriesDetail">
        <link:definition>995755 - Disclosure - Inventories, Net - Summary of Inventories (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetail" id="Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetail">
        <link:definition>995765 - Disclosure - Commitments and Contingencies - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesSummaryOfOperatingLeaseExpenseDetail" id="Role_DisclosureCommitmentsAndContingenciesSummaryOfOperatingLeaseExpenseDetail">
        <link:definition>995775 - Disclosure - Commitments and Contingencies - Summary of Operating Lease Expense (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesSummaryOfBalanceSheetClassificationOfOperatingLeaseLiabilitiesDetail" id="Role_DisclosureCommitmentsAndContingenciesSummaryOfBalanceSheetClassificationOfOperatingLeaseLiabilitiesDetail">
        <link:definition>995785 - Disclosure - Commitments and Contingencies - Summary of Balance Sheet Classification of Operating Lease Liabilities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail" id="Role_DisclosureCommitmentsAndContingenciesSummaryOfMaturitiesOfSubleaseIncomeAndOperatingLeaseLiabilitiesDetail">
        <link:definition>995795 - Disclosure - Commitments and Contingencies - Summary of Maturities of Sublease Income and Operating Lease Liabilities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesSummaryOfWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateDetail" id="Role_DisclosureCommitmentsAndContingenciesSummaryOfWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateDetail">
        <link:definition>995805 - Disclosure - Commitments and Contingencies - Summary of Weighted Average Remaining Lease Term and Weighted Average Discount Rate (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCollaborationDevelopmentAndSupplyAgreementsAdditionalInformationDetail" id="DisclosureCollaborationDevelopmentAndSupplyAgreementsAdditionalInformationDetail">
        <link:definition>995815 - Disclosure - Collaboration, Development and Supply Agreements - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureConvertibleNotesAdditionalInformationDetail" id="Role_DisclosureConvertibleNotesAdditionalInformationDetail">
        <link:definition>995825 - Disclosure - Convertible Notes - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureConvertibleNotesSummaryOfInterestExpensesRelatedToConvertibleNotesDetail" id="Role_DisclosureConvertibleNotesSummaryOfInterestExpensesRelatedToConvertibleNotesDetail">
        <link:definition>995835 - Disclosure - Convertible Notes - Summary of Interest Expenses Related to Convertible Notes (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureRevenueRecognitionSummaryOfDisaggregationOfRevenuesDetail" id="Role_DisclosureRevenueRecognitionSummaryOfDisaggregationOfRevenuesDetail">
        <link:definition>995845 - Disclosure - Revenue Recognition - Summary of Disaggregation of Revenues (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureRevenueRecognitionScheduleOfRevenuesFromMajorCustomersDetail" id="Role_DisclosureRevenueRecognitionScheduleOfRevenuesFromMajorCustomersDetail">
        <link:definition>995855 - Disclosure - Revenue Recognition - Schedule of Revenues from Major Customers (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureRevenueRecognitionSummaryOfProductRevenueAllowanceAndReserveCategoriesDetail" id="Role_DisclosureRevenueRecognitionSummaryOfProductRevenueAllowanceAndReserveCategoriesDetail">
        <link:definition>995865 - Disclosure - Revenue Recognition - Summary of Product Revenue Allowance and Reserve Categories (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureRevenueRecognitionSummaryOfBalancesAndActivitiesInOurContractAssetAccountDetails" id="DisclosureRevenueRecognitionSummaryOfBalancesAndActivitiesInOurContractAssetAccountDetails">
        <link:definition>995875 - Disclosure - Revenue Recognition - Summary of balances and activities in our contract asset account (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureComputationOfBasicAndDilutedNetLossIncomePerShareDetail" id="DisclosureComputationOfBasicAndDilutedNetLossIncomePerShareDetail">
        <link:definition>995885 - Disclosure - Computation of Basic and Diluted Net (Loss) Income Per Share (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureOutstandingStockOptionsAndStockAwardsExcludedFromCalculationOfNetLossPerShareDetail" id="Role_DisclosureOutstandingStockOptionsAndStockAwardsExcludedFromCalculationOfNetLossPerShareDetail">
        <link:definition>995895 - Disclosure - Outstanding Stock Options and Stock Awards Excluded from Calculation of Net Loss Per Share (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureCommonStockAndWarrantsAdditionalInformationDetail" id="DisclosureCommonStockAndWarrantsAdditionalInformationDetail">
        <link:definition>995905 - Disclosure - Common Stock and Warrants - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationAdditionalInformationDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationAdditionalInformationDetail">
        <link:definition>995915 - Disclosure - Equity Plans and Stock-Based Compensation - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationOptionActivityUnderStockBasedCompensationPlansDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationOptionActivityUnderStockBasedCompensationPlansDetail">
        <link:definition>995925 - Disclosure - Equity Plans and Stock-Based Compensation - Option Activity under Stock-Based Compensation Plans (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationSummaryOfRestrictedStockUnitsActivityDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationSummaryOfRestrictedStockUnitsActivityDetail">
        <link:definition>995935 - Disclosure - Equity Plans and Stock-Based Compensation - Summary of Restricted Stock Units Activity (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationSummaryOfPerformanceBasedRestrictedStockUnitDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationSummaryOfPerformanceBasedRestrictedStockUnitDetail">
        <link:definition>995945 - Disclosure - Equity Plans and Stock-Based Compensation -Summary Of Performance Based Restricted Stock Unit (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationFairValueBasedMeasurementsAndWeightedAverageAssumptionsDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationFairValueBasedMeasurementsAndWeightedAverageAssumptionsDetail">
        <link:definition>995955 - Disclosure - Equity Plans and Stock-Based Compensation - Fair Value-Based Measurements and Weighted-Average Assumptions (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/Role_DisclosureEquityPlansAndStockBasedCompensationStockBasedCompensationExpenseDetail" id="Role_DisclosureEquityPlansAndStockBasedCompensationStockBasedCompensationExpenseDetail">
        <link:definition>995965 - Disclosure - Equity Plans and Stock-Based Compensation - Stock-Based Compensation Expense (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.dynavax.com/20230930/taxonomy/role/DisclosureIncomeTaxesAdditionalInformationDetails" id="DisclosureIncomeTaxesAdditionalInformationDetails">
        <link:definition>995975 - Disclosure - Income Taxes (Additional Information) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="dvax_IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsNetOfStatutoryTaxWithholdings" name="IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsNetOfStatutoryTaxWithholdings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ScheduleOfBalanceSheetComponentsOfOperatingLeaseLiabilitiesTableTextBlock" name="ScheduleOfBalanceSheetComponentsOfOperatingLeaseLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_BadDebtExpense" name="BadDebtExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_IssuanceOfCommonStockNetOfIssuanceCostsInConjunctionWithAnUnderwrittenPublicOfferingAndAnAtMarketSalesAgreement" name="IssuanceOfCommonStockNetOfIssuanceCostsInConjunctionWithAnUnderwrittenPublicOfferingAndAnAtMarketSalesAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ReservationAgreementMember" name="ReservationAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IncreaseDecreaseInCepiAccrual" name="IncreaseDecreaseInCepiAccrual" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_BainLifeSciencesMember" name="BainLifeSciencesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ProceedsFromIssuanceOfCommonStockAuthorizedRemainingCapacity" name="ProceedsFromIssuanceOfCommonStockAuthorizedRemainingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_PreferredStockCommonStockAndWarrantsAbstract" name="PreferredStockCommonStockAndWarrantsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_PaymentReceivedForPreCommercializationMilestone" name="PaymentReceivedForPreCommercializationMilestone" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_ScheduleOfConvertibleNotesInterestExpenseTableTextBlock" name="ScheduleOfConvertibleNotesInterestExpenseTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueAbstract" name="LessorSubleaseRentalsPaymentsToBeReceivedDueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponReleaseOfRestrictedStockAwards" name="IssuanceOfCommonStockUponReleaseOfRestrictedStockAwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_PerformanceBasedRestrictedStockUnitsMember" name="PerformanceBasedRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AdvancePaymentFromCustomer" name="AdvancePaymentFromCustomer" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_CashCashEquivalentsAndMarketableSecuritiesLineItems" name="CashCashEquivalentsAndMarketableSecuritiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_NumberOfCommonStockWarrantExercised" name="NumberOfCommonStockWarrantExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_PtBioFarmaPerseroMember" name="PtBioFarmaPerseroMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ReservesAccrualBalance" name="ReservesAccrualBalance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_Sd101Member" name="Sd101Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ProductRevenueAllowanceAndReservesAdjustmentsRelatedToPriorPeriod" name="ProductRevenueAllowanceAndReservesAdjustmentsRelatedToPriorPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_DisclosureComputationOfBasicAndDilutedEarningsPerShareAbstract" name="DisclosureComputationOfBasicAndDilutedEarningsPerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceOfCommonStockNetOfIssuanceCostsInConjunctionWithAnUnderwrittenPublicOfferingAndAnAtMarketSalesAgreementShares" name="IssuanceOfCommonStockNetOfIssuanceCostsInConjunctionWithAnUnderwrittenPublicOfferingAndAnAtMarketSalesAgreementShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDue" name="LessorSubleaseRentalsPaymentsToBeReceivedDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ReclassificationOfContractAssetFromOtherCurrentAssetsToOtherAssets" name="ReclassificationOfContractAssetFromOtherCurrentAssetsToOtherAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_ThirdLargestCollaborationPartnerMember" name="ThirdLargestCollaborationPartnerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_PaymentMadeForPreCommercializationMilestone" name="PaymentMadeForPreCommercializationMilestone" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ProceedsFromExerciseOfStockOptionsAndRestrictedStockAwardsNet" name="ProceedsFromExerciseOfStockOptionsAndRestrictedStockAwardsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_BCIPLifeSciencesAssociatesLimitedPartnersMember" name="BCIPLifeSciencesAssociatesLimitedPartnersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_TrisalusLifeSciencesMember" name="TrisalusLifeSciencesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceWithholdingOfCommonStockUponExerciseOfOptionsVestingOfRestrictedStockUnitsAndVestingOfEarlyExercisedOptionsNetValue" name="IssuanceWithholdingOfCommonStockUponExerciseOfOptionsVestingOfRestrictedStockUnitsAndVestingOfEarlyExercisedOptionsNetValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_PrepaymentOfAdvancePayment" name="PrepaymentOfAdvancePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_ProductRevenueAllowanceAndReservesProvisionRelatedToCurrentPeriodSales" name="ProductRevenueAllowanceAndReservesProvisionRelatedToCurrentPeriodSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_FairValueAssetLiabilityLevel1ToLevel2TransferAmount" name="FairValueAssetLiabilityLevel1ToLevel2TransferAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_SummaryOfWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateTableTextBlock" name="SummaryOfWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRateTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_ProceedsFromGrant" name="ProceedsFromGrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_TwentySeventeenAtTheMarketAgreementMember" name="TwentySeventeenAtTheMarketAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueYearFour" name="LessorSubleaseRentalsPaymentsToBeReceivedDueYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_MaturitiesOfMarketableSecuritiesAvailableForSaleTableTextBlock" name="MaturitiesOfMarketableSecuritiesAvailableForSaleTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_ZhejiangCloverBiopharmaceuticalsIncAndCloverHongKongIncMember" name="ZhejiangCloverBiopharmaceuticalsIncAndCloverHongKongIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ValnevaSEMember" name="ValnevaSEMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IncreaseDecreaseInLeaseLiabilities" name="IncreaseDecreaseInLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_DescriptionOfAveciaSupplyAgreement" name="DescriptionOfAveciaSupplyAgreement" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_DeutscheBankSecuritiesMember" name="DeutscheBankSecuritiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueYearThree" name="LessorSubleaseRentalsPaymentsToBeReceivedDueYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_EarningsPerShareDisclosureTable" name="EarningsPerShareDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AdjustmentsToAdditionalPaidInCapitalPurchaseOfCappedCalls" name="AdjustmentsToAdditionalPaidInCapitalPurchaseOfCappedCalls" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_AdditionalFuturePayment" name="AdditionalFuturePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_HEPLISAVBMember" name="HEPLISAVBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LicenseArrangementContingentConsiderationPercentage" name="LicenseArrangementContingentConsiderationPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_IncreaseDecreaseInPrepaidManufacturing" name="IncreaseDecreaseInPrepaidManufacturing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_USDepartmentOfDefenseMember" name="USDepartmentOfDefenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_CepiAccrualLongTerm" name="CepiAccrualLongTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_LiquidityAndFinancialConditionDisclosurePolicyTextBlock" name="LiquidityAndFinancialConditionDisclosurePolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_SummaryOfProductRevenueAllowanceAndReserveCategoriesTableTextBlock" name="SummaryOfProductRevenueAllowanceAndReserveCategoriesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_SeriesBConvertiblePreferredStockMember" name="SeriesBConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AssetPurchaseAgreementMember" name="AssetPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_CoalitionForEpidemicPreparednessInnovationsAccruals" name="CoalitionForEpidemicPreparednessInnovationsAccruals" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponExerciseOfStockOptionsShares" name="IssuanceOfCommonStockUponExerciseOfStockOptionsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedRemainderOfFiscalYear" name="LessorSubleaseRentalsPaymentsToBeReceivedRemainderOfFiscalYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_StockIssuedExerciseOfWarrantsDuringPeriodValueNewIssues" name="StockIssuedExerciseOfWarrantsDuringPeriodValueNewIssues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_SerumInstituteOfIndiaPvtLtdMember" name="SerumInstituteOfIndiaPvtLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_CommonStockSalesAgreementAggregateSalesProceeds" name="CommonStockSalesAgreementAggregateSalesProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsNetOfStatutoryTaxWithholdingsShare" name="IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsNetOfStatutoryTaxWithholdingsShare" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_TwoThousandAndTwentyOneEquityIncentivePlanMember" name="TwoThousandAndTwentyOneEquityIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceOfConvertibleNotesOnPurchaseOfCappedCallOptionsValue" name="IssuanceOfConvertibleNotesOnPurchaseOfCappedCallOptionsValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_CoalitionForEpidemicPreparednessInnovationsPartnersMember" name="CoalitionForEpidemicPreparednessInnovationsPartnersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_OtherRevenueMember" name="OtherRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AdditionOfUndistributedEarningsAllocatedToParticipatingSecurities" name="AdditionOfUndistributedEarningsAllocatedToParticipatingSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ConvertibleOptionalSeniorNotesMember" name="ConvertibleOptionalSeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LicenseArrangementContingentPaymentToAcquireLicense" name="LicenseArrangementContingentPaymentToAcquireLicense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_EarningsPerShareDisclosureLineItems" name="EarningsPerShareDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_SecondLargestCollaborationPartnerMember" name="SecondLargestCollaborationPartnerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ScheduleOfPerformanceBasedRestrictedStockUnitTableTextBlock" name="ScheduleOfPerformanceBasedRestrictedStockUnitTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponExerciseOfStockOptions" name="IssuanceOfCommonStockUponExerciseOfStockOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_DebtInstrumentConversionOriginalDebtBasePrincipalAmount" name="DebtInstrumentConversionOriginalDebtBasePrincipalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_SellingCommissionPercentageFromGrossOfferingProceedsOfSalesOfStock" name="SellingCommissionPercentageFromGrossOfferingProceedsOfSalesOfStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_StockIssuedExerciseOfWarrantsDuringPeriodSharesNewIssues" name="StockIssuedExerciseOfWarrantsDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_MarketBasedPerformanceStockUnitMember" name="MarketBasedPerformanceStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AccruedResearchAndDevelopmentExpensesCurrent" name="AccruedResearchAndDevelopmentExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_TwentyTwentyAtTheMarketAgreementMember" name="TwentyTwentyAtTheMarketAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceWithholdingOfCommonStockUponExerciseOfOptionsVestingOfRestrictedStockUnitsAndVestingOfEarlyExercisedOptionsNetShares" name="IssuanceWithholdingOfCommonStockUponExerciseOfOptionsVestingOfRestrictedStockUnitsAndVestingOfEarlyExercisedOptionsNetShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_GrantAgreementMember" name="GrantAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_OtherRevenuesMember" name="OtherRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_TwoThousandAndEighteenEquityIncentivePlanMember" name="TwoThousandAndEighteenEquityIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_AccrualLongTermBalance" name="AccrualLongTermBalance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsShares" name="IssuanceOfCommonStockUponReleaseOfRestrictedStockAwardsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_CpG1018Member" name="CpG1018Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_SymphonyDynamoHoldingsLlcMember" name="SymphonyDynamoHoldingsLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_SupplyAgreementMember" name="SupplyAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_DebtInstrumentConversionPeriodOneMember" name="DebtInstrumentConversionPeriodOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_FairValueAssetLiabilityLevel2ToLevel1TransferAmount" name="FairValueAssetLiabilityLevel2ToLevel1TransferAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_MinimumAgeApprovedForVaccinePreventionOfInfectionCaused" name="MinimumAgeApprovedForVaccinePreventionOfInfectionCaused" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_VestedMember" name="VestedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_BiologicalELimitedMember" name="BiologicalELimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_InterestFreeUnsecuredForgiveableLoanMaximumBorrowingCapacity" name="InterestFreeUnsecuredForgiveableLoanMaximumBorrowingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_ProductRevenueAllowanceAndReservesCreditOrPaymentsMadeDuringPeriod" name="ProductRevenueAllowanceAndReservesCreditOrPaymentsMadeDuringPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_PercentageOfExcessRentPaidToLandlord" name="PercentageOfExcessRentPaidToLandlord" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_MedigenVaccineBiologicsMember" name="MedigenVaccineBiologicsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_PaymentToHoldings" name="PaymentToHoldings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ConvertibleSeniorNotesDueTwoThousandTwentySixMember" name="ConvertibleSeniorNotesDueTwoThousandTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_UnvestedMember" name="UnvestedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_SecondLargestCustomerMember" name="SecondLargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_PowellStreetSubleaseMember" name="PowellStreetSubleaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ConvertibleSeniorNotesMember" name="ConvertibleSeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_TwoThousandAndFourteenEmployeeStockPurchasePlanMember" name="TwoThousandAndFourteenEmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LoanAgreementMember" name="LoanAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_HortonStreetMasterLeaseMember" name="HortonStreetMasterLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LargestCustomerMember" name="LargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LargestCollaborationPartnerMember" name="LargestCollaborationPartnerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_DebtInstrumentConversionPeriodTwoMember" name="DebtInstrumentConversionPeriodTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_DebtInstrumentCappedCallTransactionInitialCapPricePerShare" name="DebtInstrumentCappedCallTransactionInitialCapPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_IncreaseInNumberOfEmployeeStockPurchasePlanSharesAuthorizedForIssuance" name="IncreaseInNumberOfEmployeeStockPurchasePlanSharesAuthorizedForIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_DebtInstrumentCappedCallTransactionInitialStrikePricePerShare" name="DebtInstrumentCappedCallTransactionInitialStrikePricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="dvax_RevenueReserveAccrualsMember" name="RevenueReserveAccrualsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_BainCapitalLifeSciencesFundLimitedPartnerMember" name="BainCapitalLifeSciencesFundLimitedPartnerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_ChangeInUnrealizedGainOnMarketableSecuritiesAvailableForSale" name="ChangeInUnrealizedGainOnMarketableSecuritiesAvailableForSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_ReclassificationOfCepiAccrualToCepiAccrualLongTerm" name="ReclassificationOfCepiAccrualToCepiAccrualLongTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_PaymentsForTaxesRelatedToNetShareSettlementOfRsus" name="PaymentsForTaxesRelatedToNetShareSettlementOfRsus" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_AmortizationOfRightOfUseAssetsAndLossOnDisposalOfPropertyAndEquipment" name="AmortizationOfRightOfUseAssetsAndLossOnDisposalOfPropertyAndEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_CashCashEquivalentsAndMarketableSecuritiesTable" name="CashCashEquivalentsAndMarketableSecuritiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_NonCashInterestExpense" name="NonCashInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_ReconciliationOfCashCashEquivalentsAndRestrictedCashToStatementOfCashFlowsTableTextBlock" name="ReconciliationOfCashCashEquivalentsAndRestrictedCashToStatementOfCashFlowsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_PerformanceBasedVestingScheduleMember" name="PerformanceBasedVestingScheduleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponExerciseOfWarrants" name="IssuanceOfCommonStockUponExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueYearFive" name="LessorSubleaseRentalsPaymentsToBeReceivedDueYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_HortonStreetSubleaseMember" name="HortonStreetSubleaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_StockOptionsAndShareAwardsMember" name="StockOptionsAndShareAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_CashSettlementOfWarrants" name="CashSettlementOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_RepaymentOfAdvanceFromCustomer" name="RepaymentOfAdvanceFromCustomer" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="dvax_CoalitionForEpidemicPreparednessInnovationsMember" name="CoalitionForEpidemicPreparednessInnovationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_IssuanceOfCommonStockUponExerciseOfWarrantsShares" name="IssuanceOfCommonStockUponExerciseOfWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueThereafter" name="LessorSubleaseRentalsPaymentsToBeReceivedDueThereafter" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="dvax_CappedCallsMember" name="CappedCallsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_CappedCallsPolicyTextBlock" name="CappedCallsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_SubleaseIncomeAndOperatingLeaseLiabilityMaturityTableTextBlock" name="SubleaseIncomeAndOperatingLeaseLiabilityMaturityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="dvax_ThirdLargestCustomerMember" name="ThirdLargestCustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_DusseldorfLeaseMember" name="DusseldorfLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="dvax_LessorSubleaseRentalsPaymentsToBeReceivedDueYearTwo" name="LessorSubleaseRentalsPaymentsToBeReceivedDueYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
</xsd:schema>
