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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 1 Months Ended 3 Months Ended 9 Months Ended
May 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
Nov. 30, 2009
USD ($)
Sep. 30, 2023
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2023
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2023
EUR (€)
Dec. 31, 2022
USD ($)
May 31, 2021
USD ($)
Loss Contingencies [Line Items]                    
Lease expiration date           Mar. 31, 2031        
Option to extend           The subtenant has no option to extend the sublease term        
Sublease income       $ 1,993 $ 2,026 $ 5,584 $ 5,660      
Percentage of excess rent paid to landlord       50.00%   50.00%   50.00%    
Cash paid for amounts included in the measurement of operating lease liabilities           $ 5,300 $ 5,100      
Long-term debt, net of debt discount       $ 3,085   3,085     $ 3,922  
Liabilities       54,264   $ 54,264     150,074  
Description of Avecia Supply Agreement           On September 7, 2023 (the “Effective Date”), we entered into an agreement (the “Avecia Supply Agreement”) with Nitto Denko Avecia Inc. (“Avecia”) for the manufacture and supply of our CpG 1018 adjuvant using a specific production process. Under the Avecia Supply Agreement, Avecia has agreed to produce and supply to us quantities of CpG 1018 adjuvant ordered by us after the Effective Date. Subject to certain conditions in the Avecia Supply Agreement, we are obligated to purchase all of our annual volume requirements of CpG 1018 adjuvant from Avecia up to a specified production capacity. We may alternatively order CpG 1018 adjuvant produced using a different production process pursuant to the existing supply agreement between us and Avecia dated October 1, 2012 (the “2012 Agreement”). As of September 30, 2023, we have not placed any manufacturing orders under the Avecia Supply Agreement. As of September 30, 2023 and December 31, 2022, we have no non-cancelable purchase and other commitments for the supply of CpG 1018 adjuvant.        
H E P L I S A V B [Member]                    
Loss Contingencies [Line Items]                    
Non-cancelable purchase and other commitments       39,800   $ 39,800     $ 43,400  
Asset Purchase Agreement                    
Loss Contingencies [Line Items]                    
Liabilities       500   500        
Symphony Dynamo Holdings LLC                    
Loss Contingencies [Line Items]                    
License arrangement contingent consideration percentage     50.00%              
License Arrangement Contingent Payment To Acquire License     $ 50,000              
TriSalus                    
Loss Contingencies [Line Items]                    
Payment to holdings           2,500        
Payment received for Pre-commercialization milestone   $ 1,000                
TriSalus | Asset Purchase Agreement                    
Loss Contingencies [Line Items]                    
Payment made for Pre-commercialization milestone $ 500                  
Deutsche Bank Securities                    
Loss Contingencies [Line Items]                    
Financial Instruments, Owned, at Fair Value | €               € 0.2    
Deutsche Bank Securities | Letter of Credit [Member]                    
Loss Contingencies [Line Items]                    
Financial Instruments, Owned, at Fair Value | €               € 0.2    
2.50% Convertible Senior Notes Due 2026                    
Loss Contingencies [Line Items]                    
Aggregate principal amount       225,500   225,500       $ 225,500
Long-term debt, net of debt discount       $ 3,100   $ 3,100        
California                    
Loss Contingencies [Line Items]                    
Lease option to extend           Certain of these leases also include options to renew or extend the lease for two successive five-year terms        
California | Maximum [Member]                    
Loss Contingencies [Line Items]                    
Initial lease term       12 years   12 years   12 years    
California | Minimum [Member]                    
Loss Contingencies [Line Items]                    
Initial lease term       3 years   3 years   3 years