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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Operating activities    
Net Income (Loss) $ (6,608) $ 225,423
Adjustments to reconcile net income to net cash (used in) provided by operating activities:    
Depreciation and amortization 3,228 2,975
Amortization of right-of-use assets and loss on disposal of property and equipment 2,090 2,244
Accretion of discounts on marketable securities (11,313) (1,969)
Change in fair value of warrant liability 0 (1,801)
Stock compensation expense 31,283 24,188
Bad debt expense (Note 6) 12,313 0
Non-cash interest expense 2,246 2,222
Inventory write-off 0 14,485
Gain on sale of assets (Note 5) (1,000) (1,000)
Changes in operating assets and liabilities:    
Accounts and other receivables, net 40,935 698
Inventories 9,435 (55,759)
Prepaid manufacturing 0 146,928
Prepaid expenses and other current assets (4,650) (26,240)
Other assets 730 61
Accounts payable (612) 301
CEPI accrual (Note 6) 0 (21,110)
Lease liabilities (2,635) (2,366)
Deferred revenue 0 (262,469)
Accrued liabilities and other liabilities 11,355 (19,043)
Net cash provided by (used in) operating activities 86,797 27,768
Investing activities    
Purchases of marketable securities (484,040) (514,676)
Proceeds from maturities of marketable securities 351,735 236,200
Purchases of property and equipment, net (2,381) (5,552)
Proceeds from sale of assets 1,000 1,000
Net cash used in investing activities (133,686) (283,028)
Financing activities    
Proceeds from warrants exercises 0 8,455
Proceeds from exercise of stock options and/or release of restricted stock awards, net 4,339 9,487
Proceeds from Employee Stock Purchase Plan 1,535 1,430
Payments for taxes related to net share settlement of RSUs (6,264) 0
Net cash provided by financing activities (390) 19,372
Effect of exchange rate changes on cash, cash equivalents and restricted cash (155) (1,755)
Net (decrease) increase in cash, cash equivalents and restricted cash (47,434) (237,643)
Cash, cash equivalents and restricted cash at beginning of period 202,211 436,408
Cash, cash equivalents and restricted cash at end of period 154,777 198,765
Supplemental disclosure of cash flow information    
Cash paid during the period for income taxes 1,413 788
Cash paid during the period for interest 2,819 2,819
Reclassification of contract asset from other current assets to other assets 71,307 0
Reclassification of CEPI accrual to CEPI accrual long-term (60,337) 0
Advance Payments forgiven per CEPI-Bio E Assignment Agreement (Note 6) (47,401) 0
Non-cash investing and financing activities:    
Purchases of property and equipment, not yet paid 704 973
Right-of-use assets obtained in exchange of lease liabilities $ 1,332 $ 2,475