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Commitments and Contingencies - Additional Information (Detail) $ in Thousands, € in Millions | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Oct. 31, 2023 USD ($) | Sep. 30, 2023 USD ($) | May 31, 2022 USD ($) | Sep. 30, 2021 USD ($) | May 31, 2021 USD ($) | Aug. 31, 2020 USD ($) | Jul. 31, 2019 | Nov. 30, 2009 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 | Dec. 31, 2023 EUR (€) | Dec. 31, 2022 EUR (€)
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease expiration date |  |  |  |  |  |  |  |  | Mar. 31, 2031 |  |  |  |  |
Option to extend |  |  |  |  |  |  |  |  | The subtenant has no option to extend the sublease term. |  |  |  |  |
Sublease income |  |  |  |  |  |  |  |  | $ 7,577 | $ 7,685 | $ 7,735 |  |  |
Percentage of excess rent paid to landlord |  |  |  |  |  |  |  |  | 50.00% |  |  |  | 50.00% |
Cash paid for amounts included in the measurement of operating lease liabilities |  |  |  |  |  |  |  |  | $ 7,200 | 6,800 | $ 7,000 |  |  |
Long-term debt discount |  |  |  |  |  |  |  |  | 2,802 | $ 3,922 |  |  |  |
Non-cancelable purchase and other commitments |  |  |  |  |  |  |  |  | $ 43,365 |  |  |  |  |
Description of Avecia Supply Agreement |  |  |  |  |  |  |  |  | On September 7, 2023 (the “Effective Date”), we entered into an agreement (the “Avecia Supply Agreement”) with Nitto Denko Avecia Inc. (“Avecia”) for the manufacture and supply of our CpG 1018 adjuvant using a specific production process. Under the Avecia Supply Agreement, Avecia has agreed to produce and supply to us quantities of CpG 1018 adjuvant ordered by us after the Effective Date. Subject to certain conditions in the Avecia Supply Agreement, we are obligated to purchase all of our annual volume requirements of CpG 1018 adjuvant from Avecia up to a specified production capacity. We may alternatively order CpG 1018 adjuvant produced using a different production process pursuant to the existing supply agreement between us and Avecia dated October 1, 2012 (the “2012 Agreement”). As of December 31, 2023, our aggregate minimum commitment for the supply of CpG 1018 adjuvant under the Avecia Supply Agreement was $7.4 million within the next 12 months. As of December 31, 2022, we had no non-cancelable purchase and other commitments for the supply of CpG 1018 adjuvant. |  |  |  |  |
Aggregate minimum commitment |  |  |  |  |  |  |  |  | $ 7,400 |  |  |  |  |
HEPLISAV-B |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-cancelable purchase and other commitments |  |  |  |  |  |  |  |  | 43,400 |  |  |  |  |
2.50% Convertible Senior Notes Due 2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  | $ 225,500 |  |  |  | 225,500 |  |  |  |  |
Long-term debt discount |  |  |  |  |  |  |  |  | $ 2,800 |  |  |  |  |
Symphony Dynamo Holdings Llc |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License arrangement contingent consideration percentage |  |  |  |  |  |  |  | 50.00% |  |  |  |  |  |
License arrangement upfront payment |  |  |  |  |  |  |  | $ 50,000 |  |  |  |  |  |
Trisalus Life Sciences |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment to holdings |  |  |  |  |  | $ 2,500 |  |  |  |  |  |  |  |
Payment received for pre-commercialization milestone |  | $ 1,000 | $ 1,000 | $ 1,000 |  |  |  |  |  |  |  |  |  |
Trisalus Life Sciences | Asset Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment made for pre-commercialization milestone | $ 500 |  |  | $ 500 | $ 500 |  |  |  |  |  |  |  |  |
Deutsche Bank Securities |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Financial instruments owned at fair value | € |  |  |  |  |  |  |  |  |  |  |  |  | € 0.2 | € 0.2
Deutsche Bank Securities | Letter of Credit |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Financial instruments owned at fair value | € |  |  |  |  |  |  |  |  |  |  |  |  | € 0.2 |
California |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease option to extend |  |  |  |  |  |  |  |  | Certain of these leases also include options to renew or extend the lease for two successive five-year terms. |  |  |  |  |
Existence of option to extend |  |  |  |  |  |  | false |  |  |  |  |  |  |
California | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial lease term |  |  |  |  |  |  |  |  | 12 years |  |  |  | 12 years |
California | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial lease term |  |  |  |  |  |  |  |  | 3 years |  |  |  | 3 years |
Powell Street Sublease | California |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Existence of option to extend |  |  |  |  |  |  |  |  |  |  |  | false |  |

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