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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 1 Months Ended 12 Months Ended
Oct. 31, 2023
USD ($)
Sep. 30, 2023
USD ($)
May 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
May 31, 2021
USD ($)
Aug. 31, 2020
USD ($)
Jul. 31, 2019
Nov. 30, 2009
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
Dec. 31, 2023
EUR (€)
Dec. 31, 2022
EUR (€)
Loss Contingencies [Line Items]                            
Lease expiration date                 Mar. 31, 2031          
Option to extend                 The subtenant has no option to extend the sublease term.          
Sublease income                 $ 7,577 $ 7,685 $ 7,735      
Percentage of excess rent paid to landlord                 50.00%       50.00%  
Cash paid for amounts included in the measurement of operating lease liabilities                 $ 7,200 6,800 $ 7,000      
Long-term debt discount                 2,802 $ 3,922        
Non-cancelable purchase and other commitments                 $ 43,365          
Description of Avecia Supply Agreement                 On September 7, 2023 (the “Effective Date”), we entered into an agreement (the “Avecia Supply Agreement”) with Nitto Denko Avecia Inc. (“Avecia”) for the manufacture and supply of our CpG 1018 adjuvant using a specific production process. Under the Avecia Supply Agreement, Avecia has agreed to produce and supply to us quantities of CpG 1018 adjuvant ordered by us after the Effective Date. Subject to certain conditions in the Avecia Supply Agreement, we are obligated to purchase all of our annual volume requirements of CpG 1018 adjuvant from Avecia up to a specified production capacity. We may alternatively order CpG 1018 adjuvant produced using a different production process pursuant to the existing supply agreement between us and Avecia dated October 1, 2012 (the “2012 Agreement”). As of December 31, 2023, our aggregate minimum commitment for the supply of CpG 1018 adjuvant under the Avecia Supply Agreement was $7.4 million within the next 12 months. As of December 31, 2022, we had no non-cancelable purchase and other commitments for the supply of CpG 1018 adjuvant.          
Aggregate minimum commitment                 $ 7,400          
HEPLISAV-B                            
Loss Contingencies [Line Items]                            
Non-cancelable purchase and other commitments                 43,400          
2.50% Convertible Senior Notes Due 2026                            
Loss Contingencies [Line Items]                            
Aggregate principal amount         $ 225,500       225,500          
Long-term debt discount                 $ 2,800          
Symphony Dynamo Holdings Llc                            
Loss Contingencies [Line Items]                            
License arrangement contingent consideration percentage               50.00%            
License arrangement upfront payment               $ 50,000            
Trisalus Life Sciences                            
Loss Contingencies [Line Items]                            
Payment to holdings           $ 2,500                
Payment received for pre-commercialization milestone   $ 1,000 $ 1,000 $ 1,000                    
Trisalus Life Sciences | Asset Purchase Agreement                            
Loss Contingencies [Line Items]                            
Payment made for pre-commercialization milestone $ 500     $ 500 $ 500                  
Deutsche Bank Securities                            
Loss Contingencies [Line Items]                            
Financial instruments owned at fair value | €                         € 0.2 € 0.2
Deutsche Bank Securities | Letter of Credit                            
Loss Contingencies [Line Items]                            
Financial instruments owned at fair value | €                         € 0.2  
California                            
Loss Contingencies [Line Items]                            
Lease option to extend                 Certain of these leases also include options to renew or extend the lease for two successive five-year terms.          
Existence of option to extend             false              
California | Maximum                            
Loss Contingencies [Line Items]                            
Initial lease term                 12 years       12 years  
California | Minimum                            
Loss Contingencies [Line Items]                            
Initial lease term                 3 years       3 years  
Powell Street Sublease | California                            
Loss Contingencies [Line Items]                            
Existence of option to extend                       false