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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 1 Months Ended 3 Months Ended 6 Months Ended
Mar. 07, 2024
USD ($)
Oct. 31, 2023
USD ($)
Sep. 30, 2023
USD ($)
May 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
Aug. 31, 2020
USD ($)
Nov. 30, 2009
USD ($)
Jun. 30, 2024
USD ($)
Jun. 30, 2023
USD ($)
Jun. 30, 2024
USD ($)
Jun. 30, 2023
USD ($)
Jun. 30, 2024
EUR (€)
Feb. 22, 2024
ft²
Dec. 31, 2023
USD ($)
May 31, 2021
USD ($)
Loss Contingencies [Line Items]                              
Lease area | ft²                         75,662    
Termination of sublease agreement $ 3,500                            
Write-off of accrued balance 4,800                            
Collection of termination payment $ 1,300                            
Sublease (expense) income (Note 5)               $ 600 $ 2,000 $ 2,200 $ 3,600        
Cash paid for amounts included in the measurement of operating lease liabilities                   3,800 $ 3,500        
Long-term debt, net of debt discount               2,228   2,228       $ 2,802  
Aggregate minimum commitment               7,400   $ 7,400       7,400  
Description of avecia supply agreement                   On September 7, 2023 (the “Effective Date”), we entered into an agreement (the “Avecia Supply Agreement”) with Nitto Denko Avecia Inc. (“Avecia”) for the manufacture and supply of our CpG 1018 adjuvant using a specific production process. Under the Avecia Supply Agreement, Avecia has agreed to produce and supply to us quantities of CpG 1018 adjuvant ordered by us after the Effective Date. Subject to certain conditions in the Avecia Supply Agreement, we are obligated to purchase all of our annual volume requirements of CpG 1018 adjuvant from Avecia up to a specified production capacity. We may alternatively order CpG 1018 adjuvant produced using a different production process pursuant to the existing supply agreement between us and Avecia dated October 1, 2012 (the “2012 Agreement”). Included in the balance of our material non-cancelable purchase and other commitments for the supply of HEPLISAV-B, as of June 30, 2024 and December 31, 2023, our aggregate minimum commitment for the supply of CpG 1018 adjuvant under the Avecia Supply Agreement totaled $7.4 million for each period, anticipated within the next 12 months.          
HEPLISAV-B                              
Loss Contingencies [Line Items]                              
Non-cancelable purchase and other commitments               38,200   $ 38,200       $ 43,400  
Symphony Dynamo Holdings LLC                              
Loss Contingencies [Line Items]                              
License arrangement contingent consideration percentage             50.00%                
License arrangement upfront payment             $ 50,000                
TriSalus                              
Loss Contingencies [Line Items]                              
Payment to holdings           $ 2,500                  
Payment received for pre-commercialization milestone     $ 1,000 $ 1,000 $ 1,000                    
TriSalus | Asset Purchase Agreement                              
Loss Contingencies [Line Items]                              
Payment made for pre-commercialization milestone   $ 500   $ 500 $ 500                    
Deutsche Bank Securities                              
Loss Contingencies [Line Items]                              
Financial instruments, owned, at fair value | €                       € 0.2      
Deutsche Bank Securities | Letter of Credit [Member]                              
Loss Contingencies [Line Items]                              
Financial instruments, owned, at fair value | €                       € 0.2      
2.50% Convertible Senior Notes Due 2026                              
Loss Contingencies [Line Items]                              
Aggregate principal amount               225,500   225,500         $ 225,500
Long-term debt, net of debt discount               $ 2,200   $ 2,200          
Emeryville, California (Premises)                              
Loss Contingencies [Line Items]                              
Lease option to extend                   Certain of these leases also include options to renew or extend the lease for two successive five-year terms          
Minimum [Member] | Emeryville, California (Premises)                              
Loss Contingencies [Line Items]                              
Lease term               3 years   3 years   3 years      
Maximum [Member] | Emeryville, California (Premises)                              
Loss Contingencies [Line Items]                              
Lease term               12 years   12 years   12 years