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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating activities |  |  |
Net income (loss) | $ 27,309 | $ (6,389) | $ 293,156
Adjustments to reconcile net income (loss) to net cash provided by operating activities: |  |  |
Depreciation and amortization | 4,627 | 4,342 | 3,812
Amortization of right-of-use assets | 3,425 | 2,934 | 2,856
Inventory write-off | 3,144 | 0 | 34,288
Sublease termination loss (Note 8) | 4,814 | 0 | 0
Amortization of premiums (accretion of discounts) on marketable securities | (14,545) | (16,555) | (4,181)
Change in fair value of warrant liability | 0 | 0 | (1,801)
Stock-based compensation expense | 52,619 | 42,592 | 32,915
Non-cash interest expense | 1,156 | 1,120 | 1,088
Gain on sale of assets | 0 | (1,000) | (1,000)
Bad debt expense (Note 9) | 0 | 12,313 | 0
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables, net | (2,373) | 43,268 | (15,699)
Inventories | (19,909) | 3,909 | (32,399)
Prepaid manufacturing | 0 | 0 | 159,655
Prepaid expenses and other current assets | (3,110) | (4,673) | (11,865)
Other assets | (1,190) | 570 | 87
Accounts payable | 3,899 | 1,952 | 691
CEPI accrual (Note 9) | 0 | 0 | (21,110)
Lease liabilities | (4,387) | (3,629) | (3,125)
Deferred revenue | 0 | 0 | (349,864)
Accrued and other liabilities | 11,033 | 19,809 | (24,788)
Net cash provided by operating activities | 66,512 | 100,563 | 62,716
Investing activities |  |  |
Purchases of marketable securities | (524,063) | (636,921) | (632,306)
Proceeds from maturities and redemptions of marketable securities | 512,380 | 486,097 | 322,450
Purchases of property and equipment, net | (6,352) | (4,104) | (7,139)
Proceeds from sale of assets, net of transaction costs | 0 | 1,000 | 1,000
Net cash used in investing activities | (18,035) | (153,928) | (315,995)
Financing activities |  |  |
Payments for repurchase of common stock | (100,000) | 0 | 0
Proceeds from warrants exercises | 0 | 0 | 8,455
Proceeds from exercise of stock options and/or release of restricted stock awards, net | 5,529 | 6,360 | 9,639
Proceeds from Employee Stock Purchase Plan | 1,760 | 1,535 | 1,431
Payments for taxes related to net share settlement of RSUs | (9,306) | (6,509) | 0
Net cash (used in) provided by financing activities | (102,017) | 1,386 | 19,525
Effect of exchange rate changes on cash and cash equivalents, and restricted cash | (862) | 324 | (443)
Net decrease in cash and cash equivalents, and restricted cash | (54,402) | (51,655) | (234,197)
Cash and cash equivalents, and restricted cash at beginning of year | 150,556 | 202,211 | 436,408
Cash and cash equivalents, and restricted cash at end of year | 96,154 | 150,556 | 202,211
Supplemental disclosure of cash flow information |  |  |
Cash paid during the year for income taxes | 4,585 | 2,014 | 2,208
Cash paid during the year for interest | 5,638 | 5,638 | 5,638
Reclassification of contract asset from other current assets to other assets | 0 | 71,307 | 0
Reclassification of CEPI accrual to CEPI accrual long-term | 0 | (60,337) | 0
Advance Payments forgiven per CEPI-Bio E Assignment Agreement (Note 9) | 0 | (47,401) | 0
Non-cash investing and financing activities: |  |  |
Purchases of property and equipment, not yet paid | 1,723 | 299 | 1,015
Right-of-use assets obtained in exchange for operating lease liabilities | $ 925 | $ 1,332 | $ 2,848

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