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Commitments and Contingencies - Narrative (Detail) $ in Thousands, € in Millions | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Oct. 31, 2023 USD ($) | Sep. 30, 2023 USD ($) | May 31, 2022 USD ($) | Sep. 30, 2021 USD ($) | May 31, 2021 USD ($) | Aug. 31, 2020 USD ($) | Nov. 30, 2009 USD ($) | Dec. 31, 2024 USD ($) renewal_term | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2024 EUR (€) renewal_term | Feb. 22, 2024 ft² | Dec. 31, 2023 EUR (€)
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Renewal term |  |  |  |  |  |  |  | 5 years |  |  | 5 years |  |
Operating lease rent area | ft² |  |  |  |  |  |  |  |  |  |  |  | 75,662 |
Sublease income |  |  |  |  |  |  |  | $ 5,014 | $ 7,577 | $ 7,685 |  |  |
Termination of sublease agreement |  |  |  |  |  |  |  | 3,500 |  |  |  |  |
Write-off of accrued balance |  |  |  |  |  |  |  | 4,800 |  |  |  |  |
Collection of termination payment |  |  |  |  |  |  |  | $ 1,300 |  |  |  |  |
Percentage of excess rent paid to landlord |  |  |  |  |  |  |  | 50.00% |  |  | 50.00% |  |
Number of renewal terms | renewal_term |  |  |  |  |  |  |  | 2 |  |  | 2 |  |
Cash paid for amounts included in the measurement of operating lease liabilities |  |  |  |  |  |  |  | $ 7,600 | 7,200 | $ 6,800 |  |  |
Non-cancelable purchase and other commitments |  |  |  |  |  |  |  | 80,550 |  |  |  |  |
Debt instrument, debt discount |  |  |  |  |  |  |  | 1,646 | $ 2,802 |  |  |  |
Symphony Dynamo Holdings Llc |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
License arrangement contingent consideration percentage |  |  |  |  |  |  | 50.00% |  |  |  |  |  |
License arrangement upfront payment |  |  |  |  |  |  | $ 50,000 |  |  |  |  |  |
Trisalus Life Sciences |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Payment to holdings |  |  |  |  |  | $ 2,500 |  |  |  |  |  |  |
Payment received for pre-commercialization milestone |  | $ 1,000 | $ 1,000 | $ 1,000 |  |  |  |  |  |  |  |  |
Trisalus Life Sciences | Asset Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Payment made for pre-commercialization milestone | $ 500 |  |  | $ 500 | $ 500 |  |  |  |  |  |  |  |
Deutsche Bank Securities |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Financial instruments owned at fair value | € |  |  |  |  |  |  |  |  |  |  | € 0.2 |  | € 0.2
Deutsche Bank Securities | Letter of Credit |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Financial instruments owned at fair value | € |  |  |  |  |  |  |  |  |  |  | € 0.2 |  |
2.50% Convertible Senior Notes Due 2026 |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  | $ 225,500 |  |  | 225,500 |  |  |  |  |
Debt instrument, debt discount |  |  |  |  |  |  |  | 1,600 |  |  |  |  |
HEPLISAV-B |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Non-cancelable purchase and other commitments |  |  |  |  |  |  |  | 80,500 |  |  |  |  |
Aggregate minimum commitment |  |  |  |  |  |  |  | 17,000 |  |  |  |  |
Aggregate minimum commitment, beyond 12 months |  |  |  |  |  |  |  | 55,400 |  |  |  |  |
CpG 1018 adjuvant |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate minimum commitment |  |  |  |  |  |  |  | $ 8,200 |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Initial lease term |  |  |  |  |  |  |  | 3 years |  |  | 3 years |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Initial lease term |  |  |  |  |  |  |  | 12 years |  |  | 12 years |  |

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