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Commitments and Contingencies - Narrative (Detail)
$ in Thousands, € in Millions
 1 Months Ended 12 Months Ended
Oct. 31, 2023
USD ($)
Sep. 30, 2023
USD ($)
May 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
May 31, 2021
USD ($)
Aug. 31, 2020
USD ($)
Nov. 30, 2009
USD ($)
Dec. 31, 2024
USD ($)
renewal_term
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2024
EUR (€)
renewal_term
Feb. 22, 2024
ft²
Dec. 31, 2023
EUR (€)
Loss Contingencies [Line Items]                          
Renewal term               5 years     5 years    
Operating lease rent area | ft²                       75,662  
Sublease income               $ 5,014 $ 7,577 $ 7,685      
Termination of sublease agreement               3,500          
Write-off of accrued balance               4,800          
Collection of termination payment               $ 1,300          
Percentage of excess rent paid to landlord               50.00%     50.00%    
Number of renewal terms | renewal_term               2     2    
Cash paid for amounts included in the measurement of operating lease liabilities               $ 7,600 7,200 $ 6,800      
Non-cancelable purchase and other commitments               80,550          
Debt instrument, debt discount               1,646 $ 2,802        
Symphony Dynamo Holdings Llc                          
Loss Contingencies [Line Items]                          
License arrangement contingent consideration percentage             50.00%            
License arrangement upfront payment             $ 50,000            
Trisalus Life Sciences                          
Loss Contingencies [Line Items]                          
Payment to holdings           $ 2,500              
Payment received for pre-commercialization milestone   $ 1,000 $ 1,000 $ 1,000                  
Trisalus Life Sciences | Asset Purchase Agreement                          
Loss Contingencies [Line Items]                          
Payment made for pre-commercialization milestone $ 500     $ 500 $ 500                
Deutsche Bank Securities                          
Loss Contingencies [Line Items]                          
Financial instruments owned at fair value | €                     € 0.2   € 0.2
Deutsche Bank Securities | Letter of Credit                          
Loss Contingencies [Line Items]                          
Financial instruments owned at fair value | €                     € 0.2    
2.50% Convertible Senior Notes Due 2026                          
Loss Contingencies [Line Items]                          
Principal amount         $ 225,500     225,500          
Debt instrument, debt discount               1,600          
HEPLISAV-B                          
Loss Contingencies [Line Items]                          
Non-cancelable purchase and other commitments               80,500          
Aggregate minimum commitment               17,000          
Aggregate minimum commitment, beyond 12 months               55,400          
CpG 1018 adjuvant                          
Loss Contingencies [Line Items]                          
Aggregate minimum commitment               $ 8,200          
Minimum                          
Loss Contingencies [Line Items]                          
Initial lease term               3 years     3 years    
Maximum                          
Loss Contingencies [Line Items]                          
Initial lease term               12 years     12 years