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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Operating activities      
Net income (loss) $ 27,309 $ (6,389) $ 293,156
Adjustments to reconcile net income (loss) to net cash provided by operating activities:      
Depreciation and amortization 4,627 4,342 3,812
Amortization of right-of-use assets 3,425 2,934 2,856
Inventory write-off 3,144 0 34,288
Sublease termination loss (Note 8) 4,814 0 0
Amortization of premiums (accretion of discounts) on marketable securities (14,545) (16,555) (4,181)
Change in fair value of warrant liability 0 0 (1,801)
Stock-based compensation expense 52,619 42,592 32,915
Non-cash interest expense 1,156 1,120 1,088
Gain on sale of assets 0 (1,000) (1,000)
Bad debt expense (Note 9) 0 12,313 0
Changes in operating assets and liabilities:      
Accounts and other receivables, net (2,373) 43,268 (15,699)
Inventories (19,909) 3,909 (32,399)
Prepaid manufacturing 0 0 159,655
Prepaid expenses and other current assets (3,110) (4,673) (11,865)
Other assets (1,190) 570 87
Accounts payable 3,899 1,952 691
CEPI accrual (Note 9) 0 0 (21,110)
Lease liabilities (4,387) (3,629) (3,125)
Deferred revenue 0 0 (349,864)
Accrued and other liabilities 11,033 19,809 (24,788)
Net cash provided by operating activities 66,512 100,563 62,716
Investing activities      
Purchases of marketable securities (524,063) (636,921) (632,306)
Proceeds from maturities and redemptions of marketable securities 512,380 486,097 322,450
Purchases of property and equipment, net (6,352) (4,104) (7,139)
Proceeds from sale of assets, net of transaction costs 0 1,000 1,000
Net cash used in investing activities (18,035) (153,928) (315,995)
Financing activities      
Payments for repurchase of common stock (100,000) 0 0
Proceeds from warrants exercises 0 0 8,455
Proceeds from exercise of stock options and/or release of restricted stock awards, net 5,529 6,360 9,639
Proceeds from Employee Stock Purchase Plan 1,760 1,535 1,431
Payments for taxes related to net share settlement of RSUs (9,306) (6,509) 0
Net cash (used in) provided by financing activities (102,017) 1,386 19,525
Effect of exchange rate changes on cash and cash equivalents, and restricted cash (862) 324 (443)
Net decrease in cash and cash equivalents, and restricted cash (54,402) (51,655) (234,197)
Cash and cash equivalents, and restricted cash at beginning of year 150,556 202,211 436,408
Cash and cash equivalents, and restricted cash at end of year 96,154 150,556 202,211
Supplemental disclosure of cash flow information      
Cash paid during the year for income taxes 4,585 2,014 2,208
Cash paid during the year for interest 5,638 5,638 5,638
Reclassification of contract asset from other current assets to other assets 0 71,307 0
Reclassification of CEPI accrual to CEPI accrual long-term 0 (60,337) 0
Advance Payments forgiven per CEPI-Bio E Assignment Agreement (Note 9) 0 (47,401) 0
Non-cash investing and financing activities:      
Purchases of property and equipment, not yet paid 1,723 299 1,015
Right-of-use assets obtained in exchange for operating lease liabilities $ 925 $ 1,332 $ 2,848