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Exhibit 12.1


Nektar Therapeutics
Statement RE: Ratio of Earnings to Fixed Charges
(in thousands, except for ratios)

 
  Year Ended December 31,
  Nine Months Ended September 30,
 
 
  2003
  2002
  2001
  2000
  1999
  2004
  2003
 
RATIO OF EARNINGS TO FIXED CHARGES                                            
Loss before income taxes and cumulative effect of accounting change   $ (65,721 ) $ (107,468 ) $ (250,008 ) $ (97,403 ) $ (38,448 ) $ (82,484 ) $ (50,194 )
Add: Fixed charges     19,670     18,293     16,297     13,726     2,470     22,847     14,762  
Less: Capitalized interest             (1,230 )                
   
 
 
 
 
 
 
 
Earnings   $ (46,051 ) $ (89,175 ) $ (234,941 ) $ (83,677 ) $ (35,978 ) $ (59,637 ) $ (35,432 )

Interest expense

 

$

17,897

 

$

16,613

 

$

13,431

 

$

12,138

 

$

2,075

 

$

21,864

 

$

13,083

 
Amortization of debt issuance costs     1,430     1,268     1,366     1,254     131     739     1,421  
Capitalized interest             1,230                  
Estimated interest portion of rental expense     343     412     270     334     264     244     258  
   
 
 
 
 
 
 
 
Fixed charges   $ 19,670   $ 18,293   $ 16,297   $ 13,726   $ 2,470   $ 22,847   $ 14,762  
   
 
 
 
 
 
 
 
Excess (deficiency) of earnings available to cover fixed charges   $ (65,721 ) $ (107,468 ) $ (251,238 ) $ (97,403 ) $ (38,448 ) $ (82,484 ) $ (50,194 )
   
 
 
 
 
 
 
 
Preference dividends   $   $   $   $   $   $   $  
   
 
 
 
 
 
 
 
Ratio of Earnings to Fixed Charges     N/A     N/A     N/A     N/A     N/A     N/A     N/A  
Ratio of Fixed Charges and Preference Dividends to Earnings     N/A     N/A     N/A     N/A     N/A     N/A     N/A  



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