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Property and Equipment - Property and Equipment (Detail) (USD $) In Thousands, unless otherwise specified | Dec. 31, 2013 | Dec. 31, 2012
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Property, Plant and Equipment [Line Items] |  |
Depreciable property and equipment at cost | $ 144,861 | $ 142,116
Less: accumulated depreciation | (84,148) | (72,666)
Depreciable property and equipment, net | 60,713 | 69,450
Construction-in-progress | 6,261 | 2,765
Property and equipment, net | 66,974 | 72,215
Building and Leasehold Improvements [Member] |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property and equipment at cost | 71,306 | 72,180
Laboratory Equipment [Member] |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property and equipment at cost | 26,621 | 27,145
Manufacturing Equipment [Member] |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property and equipment at cost | 23,699 | 20,877
Furniture, Fixtures and Other Equipment [Member] |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property and equipment at cost | $ 23,235 | $ 21,914

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- Definition Depreciable Property, plant and equipment, Net. + References No definition available. + Details
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- Definition Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.14) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 14 -Article 5 + Details
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- Definition Amount of structure or a modification to a structure under construction. Includes recently completed structures or modifications to structures that have not been placed into service. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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- Definition Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.13) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 13 -Subparagraph a -Article 5 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 8 -Article 7 + Details
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