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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) (USD $) In Thousands, unless otherwise specified | 12 Months Ended
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Total stock-based compensation | $ 17,708 | $ 16,199 | $ 18,885
Cost of Goods Sold [Member] |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Total stock-based compensation | 1,297 | 1,496 | 1,266
Research and Development [Member] |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Total stock-based compensation | 7,910 | 7,082 | 7,944
General and Administrative [Member] |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Total stock-based compensation | $ 8,501 | $ 7,621 | $ 9,675

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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