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Commitments and Contingencies - Additional Information (Detail) (USD $) | 12 Months Ended
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Contingencies And Commitments [Line Items] |  |  |
Royalty expense | $ 4,100,000 | $ 2,900,000 | $ 1,800,000
Purchase commitments related to contract manufacturing, clinical development and certain other items | 12,600,000 |  |
Litigation settlement payment description | August 1, 2007, between us (and our subsidiaries) and Bayer Healthcare LLC, as amended, related to the inhaled amikacin program in exchange for (i) a $5.0 million payment due on April 1, 2014; (ii) a $5.0 million payment due on January 1, 2015, (iii) a series of four $500,000 payments each due on April 1, 2014, January 1, 2015, January 1, 2016, and January 1, 2017, respectively; and (iv) certain other terms and conditions. |  |
Total litigation settlement payments | 12,000,000 |  |
Discount rate | 8.00% |  |
Securities Related Claims [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Obligations under Director and Officer Indemnifications per incident | 1,000,000 |  |
Non-securities Related Claims [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Obligations under Director and Officer Indemnifications per incident | 500,000 |  |
Indemnification Agreement [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Indemnification Obligations, liabilities | 0 | 0 |
Research and development expense [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Present value of settlement payments | 11,300,000 |  |
Other Current Liabilities [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Current portion of settlement liability | 5,500,000 |  |
April 1, 2014 [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Settlement installment payment due | 5,000,000 |  |
Settlement installment series payment due | 500,000 |  |
January 1, 2015 [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Settlement installment payment due | 5,000,000 |  |
Settlement installment series payment due | 500,000 |  |
January 1, 2016 [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Settlement installment series payment due | 500,000 |  |
January 1, 2017 [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Settlement installment series payment due | $ 500,000 |  |

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