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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Detail) (USD $) In Thousands, unless otherwise specified | Dec. 31, 2013 | Dec. 31, 2012
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 391,385 | $ 351,354
Research and other credits | 61,707 | 52,769
Deferred revenue | 35,588 | 39,521
Sale of future royalties | 28,057 | 39,750
Stock-based compensation | 25,962 | 23,746
Capitalized research expenses | 17,687 | 7,192
Reserves and accruals | 14,685 | 8,776
Property and equipment | 8,580 | 8,482
Other | 2,539 | 2,773
Deferred tax assets before valuation allowance | 586,190 | 534,363
Valuation allowance for deferred tax assets | (586,040) | (534,268)
Total deferred tax assets | 150 | 95
Total deferred tax liabilities |  |
Net deferred tax assets | $ 150 | $ 95

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