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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Revenue:    
Product sales and royalty revenue $ 5,917 $ 12,135
Non-cash royalty revenue related to sale of future royalties 5,773 4,393
License, collaboration and other revenue 8,081 6,476
Total revenue 19,771 23,004
Operating costs and expenses:    
Cost of goods sold 7,907 11,661
Research and development 38,338 45,618
General and administrative 9,928 10,829
Total operating costs and expenses 56,173 68,108
Loss from operations (36,402) (45,104)
Non-operating income (expense):    
Interest income 134 314
Interest expense (4,533) (4,645)
Non-cash interest expense on liability related to sale of future royalties (5,387) (5,543)
Other income (expense), net 178 127
Total non-operating expense, net (9,608) (9,747)
Loss before provision for income taxes (46,010) (54,851)
Provision for income taxes 191 212
Net loss $ (46,201) $ (55,063)
Basic and diluted net loss per share $ (0.37) $ (0.48)
Weighted average shares outstanding used in computing basic and diluted net loss per share 123,543 115,309