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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Revenue:        
Product sales and royalty revenue $ 5,891 $ 10,675 $ 11,808 $ 22,810
Non-cash royalty revenue related to sale of future royalties 4,837 3,828 10,610 8,221
License, collaboration and other revenue 17,785 19,359 25,866 25,835
Total revenue 28,513 33,862 48,284 56,866
Operating costs and expenses:        
Cost of goods sold 5,108 5,011 13,015 16,672
Research and development 36,702 52,230 75,040 97,848
General and administrative 9,619 9,226 19,547 20,057
Total operating costs and expenses 51,429 66,467 107,602 134,577
Loss from operations (22,916) (32,605) (59,318) (77,711)
Non-operating income (expense):        
Interest income 132 209 266 523
Interest expense (4,488) (4,656) (9,021) (9,301)
Non-cash interest expense on liability related to sale of future royalties (5,134) (5,485) (10,521) (11,028)
Other income (expense), net (36) (6) 142 123
Total non-operating expense, net (9,526) (9,938) (19,134) (19,683)
Loss before provision for income taxes (32,442) (42,543) (78,452) (97,394)
Provision for income taxes 195 205 386 417
Net loss $ (32,637) $ (42,748) $ (78,838) $ (97,811)
Basic and diluted net loss per share $ (0.26) $ (0.37) $ (0.63) $ (0.85)
Weighted average shares outstanding used in computing basic and diluted net loss per share 127,040 115,544 125,301 115,427