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Income Taxes - Income Tax Provision Related to Continuing Operations (Detail) (USD $) In Thousands, unless otherwise specified | 12 Months Ended
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Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
U.S. federal provision (benefit) |  |  |
At statutory rate | $ (19,050)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate | $ (55,919)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate | $ (60,007)us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
State taxes | 1 us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes | 50 us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes | (48)us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes
Change in valuation allowance | 11,831 us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance | 55,042 us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance | 47,349 us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
Non-cash interest expense on liability related to sale of future royalties | 7,311 us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther | 7,808 us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther | 6,320 us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther
Stock-based compensation | 2,832 us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost | 271 us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost | 236 us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost
Foreign tax inclusion |  |  | 6,510 us-gaap_IncomeTaxReconciliationTaxSettlementsForeign
Foreign tax differential | (17)us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential | (20)us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential | (227)us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential
Research credits | (2,933)us-gaap_IncomeTaxReconciliationTaxCreditsResearch | (6,273)us-gaap_IncomeTaxReconciliationTaxCreditsResearch | (591)us-gaap_IncomeTaxReconciliationTaxCreditsResearch
Other | (487)us-gaap_IncomeTaxReconciliationOtherAdjustments | 1,286 us-gaap_IncomeTaxReconciliationOtherAdjustments | 864 us-gaap_IncomeTaxReconciliationOtherAdjustments
(Benefit) provision for income taxes | $ (512)us-gaap_IncomeTaxExpenseBenefit | $ 2,245 us-gaap_IncomeTaxExpenseBenefit | $ 406 us-gaap_IncomeTaxExpenseBenefit

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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph h -Article 4 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Income Tax Expense (or Benefit) -URI http://asc.fasb.org/extlink&oid=6515339 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319 + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32698-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 45 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=37586315&loc=d3e32123-109318 + Details
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- Definition The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32698-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph h -Subparagraph 2 -Article 4 + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to nondeductible equity-based compensation costs. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32698-109319 + Details
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