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Selected Quarterly Financial Data - Quarterly Financial Data (Detail) (USD $) In Thousands, except Per Share data, unless otherwise specified | 3 Months Ended | 12 Months Ended
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Dec. 31, 2014 | Sep. 30, 2014 | Jun. 30, 2014 | Mar. 31, 2014 | Dec. 31, 2013 | Sep. 30, 2013 | Jun. 30, 2013 | Mar. 31, 2013 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
Income Statement [Abstract] |  |  |  |  |  |  |  |  |  |  |
Product sales | $ 7,460 us-gaap_SalesRevenueGoodsNet | $ 6,096 us-gaap_SalesRevenueGoodsNet | $ 5,802 us-gaap_SalesRevenueGoodsNet | $ 5,795 us-gaap_SalesRevenueGoodsNet | $ 8,040 us-gaap_SalesRevenueGoodsNet | $ 14,672 us-gaap_SalesRevenueGoodsNet | $ 10,324 us-gaap_SalesRevenueGoodsNet | $ 11,810 us-gaap_SalesRevenueGoodsNet | $ 25,152 us-gaap_SalesRevenueGoodsNet | $ 44,846 us-gaap_SalesRevenueGoodsNet | $ 35,399 us-gaap_SalesRevenueGoodsNet
Total revenue | 19,551 us-gaap_Revenues | 132,871 us-gaap_Revenues | 28,513 us-gaap_Revenues | 19,771 us-gaap_Revenues | 31,146 us-gaap_Revenues | 60,909 us-gaap_Revenues | 33,862 us-gaap_Revenues | 23,004 us-gaap_Revenues | 200,707 us-gaap_Revenues | 148,921 us-gaap_Revenues | 81,191 us-gaap_Revenues
Cost of goods sold | 6,298 us-gaap_CostOfGoodsSold | 9,220 us-gaap_CostOfGoodsSold | 5,108 us-gaap_CostOfGoodsSold | 7,907 us-gaap_CostOfGoodsSold | 8,960 us-gaap_CostOfGoodsSold | 12,877 us-gaap_CostOfGoodsSold | 5,011 us-gaap_CostOfGoodsSold | 11,661 us-gaap_CostOfGoodsSold | 28,533 us-gaap_CostOfGoodsSold | 38,509 us-gaap_CostOfGoodsSold | 30,428 us-gaap_CostOfGoodsSold
Research and development expenses | 38,494 us-gaap_ResearchAndDevelopmentExpense | 34,200 us-gaap_ResearchAndDevelopmentExpense | 36,702 us-gaap_ResearchAndDevelopmentExpense | 38,338 us-gaap_ResearchAndDevelopmentExpense | 48,248 us-gaap_ResearchAndDevelopmentExpense | 43,914 us-gaap_ResearchAndDevelopmentExpense | 52,230 us-gaap_ResearchAndDevelopmentExpense | 45,618 us-gaap_ResearchAndDevelopmentExpense | 147,734 us-gaap_ResearchAndDevelopmentExpense | 190,010 us-gaap_ResearchAndDevelopmentExpense | 148,675 us-gaap_ResearchAndDevelopmentExpense
Operating income (loss) | (37,488)us-gaap_OperatingIncomeLoss | 80,321 us-gaap_OperatingIncomeLoss | (22,916)us-gaap_OperatingIncomeLoss | (36,402)us-gaap_OperatingIncomeLoss | (35,894)us-gaap_OperatingIncomeLoss | (6,525)us-gaap_OperatingIncomeLoss | (32,605)us-gaap_OperatingIncomeLoss | (45,106)us-gaap_OperatingIncomeLoss | (16,485)us-gaap_OperatingIncomeLoss | (120,130)us-gaap_OperatingIncomeLoss | (141,201)us-gaap_OperatingIncomeLoss
Net income (loss) | $ (45,683)us-gaap_NetIncomeLoss | $ 70,605 us-gaap_NetIncomeLoss | $ (32,637)us-gaap_NetIncomeLoss | $ (46,201)us-gaap_NetIncomeLoss | $ (47,659)us-gaap_NetIncomeLoss | $ (16,543)us-gaap_NetIncomeLoss | $ (42,748)us-gaap_NetIncomeLoss | $ (55,063)us-gaap_NetIncomeLoss | $ (53,916)us-gaap_NetIncomeLoss | $ (162,013)us-gaap_NetIncomeLoss | $ (171,855)us-gaap_NetIncomeLoss
Net income (loss) per share |  |  |  |  |  |  |  |  |  |  |
Basic | $ (0.35)us-gaap_EarningsPerShareBasic | $ 0.55 us-gaap_EarningsPerShareBasic | $ (0.26)us-gaap_EarningsPerShareBasic | $ (0.37)us-gaap_EarningsPerShareBasic | $ (0.41)us-gaap_EarningsPerShareBasic | $ (0.14)us-gaap_EarningsPerShareBasic | $ (0.37)us-gaap_EarningsPerShareBasic | $ (0.48)us-gaap_EarningsPerShareBasic |  |  |
Diluted | $ (0.35)us-gaap_EarningsPerShareDiluted | $ 0.53 us-gaap_EarningsPerShareDiluted | $ (0.26)us-gaap_EarningsPerShareDiluted | $ (0.37)us-gaap_EarningsPerShareDiluted | $ (0.41)us-gaap_EarningsPerShareDiluted | $ (0.14)us-gaap_EarningsPerShareDiluted | $ (0.37)us-gaap_EarningsPerShareDiluted | $ (0.48)us-gaap_EarningsPerShareDiluted |  |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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