Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	3 Months Ended
Mar. 31, 2015	Mar. 31, 2014
Cash flows from operating activities:
Net income (loss)	$ 33,820us-gaap_NetIncomeLoss	$ (46,201)us-gaap_NetIncomeLoss
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Non-cash royalty revenue related to sale of future royalties	(3,962)	(5,773)
Non-cash interest expense on liability related to sale of future royalties	5,050	5,387
Stock-based compensation	5,177	4,361
Depreciation and amortization	2,973us-gaap_DepreciationAndAmortization	3,264us-gaap_DepreciationAndAmortization
Other non-cash transactions	(938)us-gaap_OtherNoncashIncomeExpense	777us-gaap_OtherNoncashIncomeExpense
Changes in operating assets and liabilities:
Accounts receivable, net	722	374
Inventory	441us-gaap_IncreaseDecreaseInInventories	580us-gaap_IncreaseDecreaseInInventories
Other assets	2,809	(718)
Accounts payable	2,241	(6,126)
Accrued compensation	3,607	(4,827)
Accrued expenses	1,811	693
Accrued clinical trial expenses	1,039	(3,179)
Interest payable	(3,750)	(3,750)
Deferred revenue	1,993	(5,957)
Other liabilities	10,279	(1,195)
Net cash provided by (used in) operating activities	63,312	(62,290)
Cash flows from investing activities:
Maturities of investments	73,434	56,972
Purchases of investments	(24,432)	(110,661)
Sale of investments	5,215
Purchases of property, plant and equipment	(1,059)	(4,524)
Net cash provided by (used in) investing activities	53,158	(58,213)
Cash flows from financing activities:
Payment of capital lease obligations	(1,098)	(825)
Repayment of proceeds from sale of future royalties		(7,000)
Issuance of common stock, net of issuance costs		116,619
Proceeds from shares issued under equity compensation plans	1,685	5,074
Net cash provided by financing activities	587	113,868
Effect of exchange rates on cash and cash equivalents	30	11
Net increase (decrease) in cash and cash equivalents	117,087	(6,624)
Cash and cash equivalents at beginning of period	12,365	39,067
Cash and cash equivalents at end of period	129,452	32,443
Supplemental disclosure of cash flow information:
Cash paid for interest	$ 7,855us-gaap_InterestPaid	$ 7,961us-gaap_InterestPaid

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-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3179-108585

+ Details

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Namespace Prefix:	us-gaap_
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Balance Type:	debit
Period Type:	duration

- Definition

The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 15

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3291-108585

+ Details

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- Details

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