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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Revenue:        
Product sales and royalty revenue $ 11,713 $ 5,891 $ 19,812 $ 11,808
Non-cash royalty revenue related to sale of future royalties 4,740 4,837 8,702 10,610
License, collaboration and other revenue 6,208 17,785 102,948 25,866
Total revenue 22,661 28,513 131,462 48,284
Operating costs and expenses:        
Cost of goods sold 10,534 5,108 18,978 13,015
Research and development 45,412 36,702 92,423 75,040
General and administrative 10,184 9,619 20,487 19,547
Total operating costs and expenses 66,130 51,429 131,888 107,602
Loss from operations (43,469) (22,916) (426) (59,318)
Non-operating income (expense):        
Interest expense (4,118) (4,488) (8,289) (9,021)
Non-cash interest expense on liability related to sale of future royalties (5,152) (5,134) (10,202) (10,521)
Interest income and other income (expense), net 246 96 457 408
Total non-operating expense, net (9,024) (9,526) (18,034) (19,134)
Loss before provision for income taxes (52,493) (32,442) (18,460) (78,452)
Provision for income taxes 164 195 377 386
Net loss $ (52,657) $ (32,637) $ (18,837) $ (78,838)
Basic and diluted net loss per share $ (0.40) $ (0.26) $ (0.14) $ (0.63)
Weighted average shares outstanding used in computing basic and diluted net loss per share 131,643 127,040 131,502 125,301