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Commitments and Contingencies - Additional Information (Detail) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Aug. 14, 2015
Loss Contingencies [Line Items] |  |  |  |
Royalty expense | $ 2,800,000 | $ 3,400,000 | $ 4,100,000 |
Purchase commitments related to contract manufacturing, clinical development and certain other items | 5,400,000 |  |  |
Damage claim for unpaid licensing fee |  |  |  | $ 1,500,000
Indemnification Obligation [Member] |  |  |  |
Loss Contingencies [Line Items] |  |  |  |
Indemnification obligations, liabilities | 0 | $ 0 |  |
Merger and Acquisition Related Claims [Member] |  |  |  |
Loss Contingencies [Line Items] |  |  |  |
Obligations under Director and Officer Indemnifications per incident | 1,500,000 |  |  |
Securities Related Claims [Member] |  |  |  |
Loss Contingencies [Line Items] |  |  |  |
Obligations under Director and Officer Indemnifications per incident | 1,000,000 |  |  |
Non-Securities Related Claims [Member] |  |  |  |
Loss Contingencies [Line Items] |  |  |  |
Obligations under Director and Officer Indemnifications per incident | $ 500,000 |  |  |

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- Definition Royalty expense incurred and are directly related to goods produced and sold and services rendered during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(a),(d)) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 + Details
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