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v3.3.1.900

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenue: |  |  |
Product sales | $ 40,155 | $ 25,152 | $ 44,846
Royalty revenue | 2,967 | 329 | 1,148
Non-cash royalty revenue related to sale of future royalties | 22,058 | 21,937 | 22,055
License, collaboration and other revenue | 165,604 | 153,289 | 80,872
Total revenue | 230,784 | 200,707 | 148,921
Operating costs and expenses: |  |  |
Cost of goods sold | 34,102 | 28,533 | 38,509
Research and development | 182,787 | 147,734 | 190,010
General and administrative | 43,266 | 40,925 | 40,532
Total operating costs and expenses | 260,155 | 217,192 | 269,051
Loss from operations | (29,371) | (16,485) | (120,130)
Non-operating income (expense): |  |  |
Interest expense | (18,282) | (17,869) | (18,453)
Non-cash interest expense on liability related to sale of future royalties | (20,619) | (20,888) | (22,309)
Loss on extinguishment of debt | (14,079) | 0 | 0
Interest income and other income (expense), net | 1,680 | 814 | 1,124
Total non-operating expense, net | (51,300) | (37,943) | (39,638)
Loss before provision (benefit) for income taxes | (80,671) | (54,428) | (159,768)
Provision (benefit) for income taxes | 506 | (512) | 2,245
Net loss | $ (81,177) | $ (53,916) | $ (162,013)
Basic and diluted net loss per share | $ (0.61) | $ (0.42) | $ (1.40)
Weighted average shares outstanding used in computing basic and diluted net loss per share | 132,458 | 126,873 | 115,732

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