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Selected Quarterly Financial Data - Quarterly Financial Data (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2014 | Sep. 30, 2014 | Jun. 30, 2014 | Mar. 31, 2014 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Income Statement [Abstract] |  |  |  |  |  |  |  |  |  |  |
Product sales | $ 13,973 | $ 7,240 | $ 10,968 | $ 7,974 | $ 7,460 | $ 6,096 | $ 5,802 | $ 5,795 | $ 40,155 | $ 25,152 | $ 44,846
Total revenue | 39,370 | 59,952 | 22,661 | 108,801 | 19,551 | 132,871 | 28,513 | 19,771 | 230,784 | 200,707 | 148,921
Cost of goods sold | 8,364 | 6,760 | 10,534 | 8,444 | 6,298 | 9,220 | 5,108 | 7,907 | 34,102 | 28,533 | 38,509
Research and development expenses | 47,135 | 43,229 | 45,412 | 47,011 | 38,494 | 34,200 | 36,702 | 38,338 | 182,787 | 147,734 | 190,010
Operating income (loss) | (29,364) | 419 | (43,469) | 43,043 | (37,488) | 80,321 | (22,916) | (36,402) | (29,371) | (16,485) | (120,130)
Net income (loss) | $ (54,137) | $ (8,203) | $ (52,657) | $ 33,820 | $ (45,683) | $ 70,605 | $ (32,637) | $ (46,201) | $ (81,177) | $ (53,916) | $ (162,013)
Net income (loss) per share |  |  |  |  |  |  |  |  |  |  |
Basic | $ (0.40) | $ (0.06) | $ (0.40) | $ 0.26 | $ (0.35) | $ 0.55 | $ (0.26) | $ (0.37) |  |  |
Diluted | $ (0.40) | $ (0.06) | $ (0.40) | $ 0.25 | $ (0.35) | $ 0.53 | $ (0.26) | $ (0.37) |  |  |

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