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Liability Related to the Sale of Future Royalties - Additional Information (Detail) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended | 46 Months Ended
--- | --- | --- | --- | ---
Feb. 24, 2012 | Mar. 31, 2014 | Mar. 31, 2013 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2015
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Royalty agreement contingent payment description |  |  |  | As a result of worldwide net sales of MIRCERA® for the 12 month periods ended December 31, 2013 and 2012 not reaching certain minimum thresholds. |  |  |
Non-cash royalty revenue related to sale of future royalties |  |  |  | $ 22,058 | $ 21,937 | $ 22,055 | $ 76,841
Non-cash interest expense on liability related to sale of future royalties |  |  |  | $ 20,619 | $ 20,888 | $ 22,309 | $ 81,873
Annual interest rate |  |  |  | 17.00% |  |  |
Purchase and Sale Agreement with RPI [Member] |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Proceeds from sale of royalty rights | $ 124,000 |  |  |  |  |  |
Transaction costs related to sale of potential future royalties | $ 4,400 |  |  |  |  |  |
Payment made for milestone not achieved year two |  | $ 7,000 |  |  |  |  |
Payment made for milestone not achieved year one |  |  | $ 3,000 |  |  |  |

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