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License and Collaboration Agreements - License, Collaboration and Other Revenue (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 34,187 $ 96,740
AstraZeneca AB [Member] | MOVANTIKTM (NKTR-118) and MOVANTIKTM fixed-dose combination program (NKTR-119) [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 28,000 90,000
Roche [Member] | PEGASYS and MIRCERA [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 1,929 3,212
Amgen, Inc. [Member] | Neulasta [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 1,250 1,250
Bayer Healthcare LLC [Member] | BAY41-6551 (Amikacin Inhale) [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 357 810
Baxalta Incorporated [Member] | ADYNOVATETM [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 104 109
Other [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 2,547 $ 1,359