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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Revenue:    
Product sales $ 14,099 $ 7,974
Royalty revenue 4,061 125
Non-cash royalty revenue related to sale of future royalties 6,535 3,962
License, collaboration and other revenue 34,187 96,740
Total revenue 58,882 108,801
Operating costs and expenses:    
Cost of goods sold 8,870 8,444
Research and development 49,268 47,011
General and administrative 10,228 10,303
Total operating costs and expenses 68,366 65,758
Income (loss) from operations (9,484) 43,043
Non-operating income (expense):    
Interest expense (5,677) (4,171)
Non-cash interest expense on liability related to sale of future royalties (5,045) (5,050)
Interest income and other income (expense), net 875 211
Total non-operating expense, net (9,847) (9,010)
Income (loss) before provision for income taxes (19,331) 34,033
Provision for income taxes 167 213
Net income (loss) $ (19,498) $ 33,820
Net income (loss) per share:    
Basic $ (0.14) $ 0.26
Diluted $ (0.14) $ 0.25
Weighted average shares outstanding used in computing net income (loss) per share:    
Basic 135,793 131,359
Diluted 135,793 135,667