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v3.5.0.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2016 | Jun. 30, 2015
Cash flows from operating activities: |  |
Net loss | $ (68,101) | $ (18,837)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (14,650) | (8,702)
Non-cash interest expense on liability related to sale of future royalties | 10,027 | 10,202
Stock-based compensation | 12,627 | 9,737
Depreciation and amortization | 7,634 | 5,833
Other non-cash transactions | (1,260) | (621)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (7,830) | (73)
Inventory | 1,084 | 2,828
Other assets | 4,637 | 190
Accounts payable | 17 | (10)
Accrued compensation | 6,465 | 5,075
Accrued clinical trial expenses | 5,250 | 1,238
Other accrued expenses | 2,831 | 1,859
Interest payable | (54) | 0
Liability related to refundable upfront payment | 12,500 | 0
Deferred revenue | (7,704) | (4,434)
Other liabilities | (725) | 11,772
Net cash (used in) provided by operating activities | (37,252) | 16,057
Cash flows from investing activities: |  |
Purchases of investments | (72,806) | (124,468)
Maturities of investments | 107,363 | 111,001
Sales of investments | 0 | 5,215
Purchases of property, plant and equipment | (3,234) | (4,584)
Net cash provided by (used in) investing activities | 31,323 | (12,836)
Cash flows from financing activities: |  |
Payment of capital lease obligations | (3,517) | (2,484)
Proceeds from shares issued under equity compensation plans | 9,643 | 7,798
Net cash provided by financing activities | 6,126 | 5,314
Effect of exchange rates on cash and cash equivalents | (91) | (25)
Net increase in cash and cash equivalents | 106 | 8,510
Cash and cash equivalents at beginning of period | 55,570 | 12,365
Cash and cash equivalents at end of period | 55,676 | 20,875
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 10,448 | $ 8,320

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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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