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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 508,406 | $ 447,761
Research and other credits | 74,917 | 70,258
Stock-based compensation | 26,357 | 22,832
Deferred revenue | 23,035 | 29,658
Reserves and accruals | 12,269 | 8,309
Capitalized research expenses | 11,587 | 12,440
Property, plant and equipment | 6,882 | 6,451
Sale of future royalties | 1,611 | 12,319
Other | 750 | 3,158
Deferred tax assets before valuation allowance | 665,814 | 613,186
Valuation allowance for deferred tax assets | (665,514) | (612,996)
Total deferred tax assets | 300 | 190
Total deferred tax liabilities | 0 | 0
Net deferred tax assets | $ 300 | $ 190

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