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Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Income Taxes Disclosure [Line Items] |  |  |
Statutory income tax rate | 35.00% |  |
Increase in valuation allowance | $ 52,500 | $ 17,300 |
Valuation allowance related to stock-based compensation and exercises prior to the implementation of ASC 515 and 718 | 35,600 | 35,600 |
Deferred U.S. income taxes | 0 | 0 | $ 0
Income taxes have not been provided on a cumulative total | 3,400 |  |
Income tax research credits | 4,543 | $ 4,529 | $ 2,933
Federal orphan drug credits | $ 17,700 |  |
Federal orphan drug credits, expiration year | 2026 |  |
Unrecognized tax benefits, period may increase or decrease due to tax examination | Next twelve months |  |
Federal [Member] |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss carryforward for income tax | $ 1,413,300 |  |
Net operating loss carryforward, expiration year | 2018 |  |
Income tax research credits | $ 50,100 |  |
Income tax research credits, expiration year | 2019 |  |
State [Member] |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss carryforward for income tax | $ 473,600 |  |
Net operating loss carryforward, expiration year | 2017 |  |
Income tax research credits | $ 25,200 |  |

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