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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands, shares in Millions |  | 12 Months Ended
--- | --- | ---
Jan. 01, 2016 USD ($) | Dec. 31, 2016 USD ($) Customer Reporting_Unit shares | Dec. 31, 2015 USD ($) Customer shares | Dec. 31, 2014 shares
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cash and investments in marketable securities |  | $ 389,102 | $ 308,944 |
Senior secured notes |  | 250,000 |  |
Debt and capital lease obligation |  | 255,100 |  |
Capital lease obligations |  | 5,100 |  |
Capital lease obligations, current portion |  | $ 2,908 | $ 4,756 |
Number of customers accounted for major accounts receivable | Customer |  | 3 | 3 |
Percentage of accounts receivable customers one |  | 39.00% | 50.00% |
Percentage of accounts receivable customers two |  | 32.00% | 35.00% |
Percentage of accounts receivable customers three |  | 13.00% | 10.00% |
Number of reporting unit evaluated for goodwill | Reporting_Unit |  | 1 |  |
Minimum percentage of amount realized upon ultimate settlement |  | 50.00% |  |
Senior Secured Notes [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Reclassification of capitalized issuance costs | $ 400 |  |  |
Liability Related To Future Royalties Liability Balances [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Reclassification of capitalized issuance costs | $ 3,000 |  |  |
Stock Options and Restricted Stock Units [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Weighted average diluted securities excluded from diluted net loss per share | shares |  | 19.9 | 21.1 | 21.9
Buildings [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives |  | 20 years |  |
Manufacturing Laboratory and Other Equipment [Member] | Minimum [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives |  | 3 years |  |
Manufacturing Laboratory and Other Equipment [Member] | Maximum [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives |  | 10 years |  |

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