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License and Collaboration Agreements - License, Collaboration and Other Revenue (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 6,092 $ 34,187
AstraZeneca AB [Member] | MOVANTIK and MOVANTIK fixed-dose combination program [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 3,000 28,000
Amgen, Inc. [Member] | Neulasta [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 1,250 1,250
Bayer Healthcare LLC [Member] | BAY41-6551 (Amikacin Inhale) [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 357 357
Daiichi Sankyo Europe GmbH [Member] | ONZEALDTM (NKTR-102) [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 216 0
Roche [Member] | MIRCERA [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 0 1,929
Baxalta Incorporated [Member] | ADYNOVATE [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 0 104
Other [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 1,269 $ 2,547