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v3.8.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2017 | Sep. 30, 2016
Cash flows from operating activities: |  |
Net loss | $ (62,866) | $ (111,325)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (21,367) | (22,341)
Non-cash interest expense on liability related to sale of future royalties | 13,535 | 14,929
Stock-based compensation | 25,118 | 18,793
Depreciation and amortization | 12,081 | 11,502
Other non-cash transactions | (1,370) | (2,190)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 12,364 | 5,698
Inventory | (2,545) | 592
Other assets | (2,036) | 6,041
Accounts payable | 5,729 | 4,799
Accrued compensation | 808 | 9,735
Accrued clinical trial expenses | (958) | 2,726
Other accrued expenses | 4,971 | 2,386
Liability related to refundable upfront payment | 0 | 12,500
Deferred revenue | 15,477 | (12,665)
Other liabilities | 1,046 | (5,793)
Net cash used in operating activities | (13) | (64,613)
Cash flows from investing activities: |  |
Purchases of investments | (314,439) | (142,972)
Maturities of investments | 261,112 | 201,449
Sales of investments | 8,823 | 4,969
Purchases of property, plant and equipment | (7,283) | (3,741)
Net cash (used in) provided by investing activities | (51,787) | 59,705
Cash flows from financing activities: |  |
Payment of capital lease obligations | (2,159) | (5,376)
Proceeds from shares issued under equity compensation plans | 32,275 | 18,041
Net cash provided by financing activities | 30,116 | 12,665
Effect of exchange rates on cash and cash equivalents | 11 | (32)
Net (decrease) increase in cash and cash equivalents | (21,673) | 7,725
Cash and cash equivalents at beginning of period | 59,640 | 55,570
Cash and cash equivalents at end of period | 37,967 | 63,295
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 14,989 | $ 15,513

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