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v3.8.0.1

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue: |  |  |
Product sales | $ 32,688 | $ 55,354 | $ 40,155
Royalty revenue | 33,527 | 19,542 | 2,967
Non-cash royalty revenue related to sale of future royalties | 30,531 | 30,158 | 22,058
License, collaboration and other revenue | 210,965 | 60,382 | 165,604
Total revenue | 307,711 | 165,436 | 230,784
Operating costs and expenses: |  |  |
Cost of goods sold | 30,547 | 30,215 | 34,102
Research and development | 268,461 | 203,801 | 182,787
General and administrative | 52,364 | 44,275 | 43,266
Impairment of equipment and other costs for terminated program | 15,981 | 0 | 0
Total operating costs and expenses | 367,353 | 278,291 | 260,155
Loss from operations | (59,642) | (112,855) | (29,371)
Non-operating income (expense): |  |  |
Interest expense | (22,085) | (22,468) | (18,282)
Non-cash interest expense on liability related to sale of future royalties | (18,869) | (19,712) | (20,619)
Loss on extinguishment of debt | 0 | 0 | (14,079)
Interest income and other income (expense), net | 4,520 | 2,387 | 1,680
Total non-operating expense, net | (36,434) | (39,793) | (51,300)
Loss before provision for income taxes | (96,076) | (152,648) | (80,671)
Provision for income taxes | 616 | 876 | 506
Net loss | $ (96,692) | $ (153,524) | $ (81,177)
Basic and diluted net loss per share | $ (0.62) | $ (1.10) | $ (0.61)
Weighted average shares outstanding used in computing basic and diluted net loss per share | 155,953 | 139,596 | 132,458

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