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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities: |  |  |
Net loss | $ (96,692) | $ (153,524) | $ (81,177)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Non-cash royalty revenue related to sale of future royalties | (30,531) | (30,158) | (22,058)
Non-cash interest expense on liability related to sale of future royalties | 18,869 | 19,712 | 20,619
Stock-based compensation | 36,615 | 25,850 | 19,669
Depreciation and amortization | 14,741 | 15,351 | 12,855
Loss from redemption premium and incremental interest on 12% senior secured notes | 0 | 0 | 12,500
Write-off of deferred financing costs on 12% senior secured notes | 0 | 0 | 1,579
Impairment of equipment from terminated program | 15,081 | 0 | 0
Other non-cash transactions | (881) | (2,185) | (2,365)
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | 10,664 | 4,269 | (16,340)
Inventory | 383 | 237 | 1,606
Other assets | (4,800) | (312) | (825)
Accounts payable | 2,074 | 518 | (412)
Accrued compensation | (10,017) | 12,282 | 249
Accrued clinical trial expenses | 1,503 | (262) | 512
Other accrued expenses | 5,774 | 191 | (2,278)
Interest payable | 0 | 0 | (2,719)
Liability related to refundable upfront payment | (12,500) | 12,500 | 0
Deferred revenue | (28,269) | (17,615) | (17,530)
Other liabilities | (2,428) | (3,878) | 3,032
Net cash used in operating activities | (80,414) | (117,024) | (73,083)
Cash flows from investing activities: |  |  |
Purchases of investments | (404,425) | (334,659) | (297,608)
Maturities of investments | 347,743 | 253,682 | 226,923
Sales of investments | 37,549 | 4,969 | 42,544
Release of restricted cash | 0 | 0 | 25,000
Purchases of property, plant and equipment | (9,676) | (6,392) | (11,195)
Net cash used in investing activities | (28,809) | (82,400) | (14,336)
Cash flows from financing activities: |  |  |
Payment of capital lease obligations | (5,131) | (5,945) | (5,187)
Proceeds from shares issued under equity compensation plans | 59,522 | 20,287 | 32,208
Issuance of common stock, net of issuance costs | 0 | 189,276 | 0
Proceeds from issuance of 7.75% senior secured notes, net of issuance costs | 0 | 0 | 241,262
Repayment of 12% senior secured notes | 0 | 0 | (125,000)
Payment of redemption premium and incremental interest on 12% senior secured notes | 0 | 0 | (12,500)
Net cash provided by financing activities | 54,391 | 203,618 | 130,783
Effect of exchange rates on cash and cash equivalents | (46) | (124) | (159)
Net increase (decrease) in cash and cash equivalents | (54,878) | 4,070 | 43,205
Cash and cash equivalents at beginning of year | 59,640 | 55,570 | 12,365
Cash and cash equivalents at end of year | 4,762 | 59,640 | 55,570
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 20,116 | 20,589 | 20,225
Cash paid for income taxes | $ 556 | $ 757 | $ 860

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- Definition The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from issuance of shares under share-based compensation arrangement, excluding stock option exercises. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=96867065&loc=SL79508275-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition The cash outflow for a long-term debt where the holder has highest claim on the entity's asset in case of bankruptcy or liquidation during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- References No definition available. + Details
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- Definition Write-off of amounts previously capitalized as debt issuance cost in an extinguishment of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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