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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 364,864 | $ 508,406
Research and other credits | 94,103 | 74,917
Stock-based compensation | 14,552 | 26,357
Property, plant and equipment | 6,848 | 6,882
Reserves and accruals | 5,659 | 12,269
Capitalized research expenses | 5,497 | 11,587
Deferred revenue | 3,796 | 23,035
Sale of future royalties | 0 | 1,611
Other | 1,156 | 750
Deferred tax assets before valuation allowance | 496,475 | 665,814
Valuation allowance for deferred tax assets | (496,191) | (665,514)
Total deferred tax assets | 284 | 300
Total deferred tax liabilities | 0 | 0
Net deferred tax assets | $ 284 | $ 300

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