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Income Taxes - Income Tax Provision Related to Continuing Operations (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
U.S. federal provision (benefit) |  |  |
At statutory rate | $ (33,627) | $ (53,427) | $ (28,235)
Tax law changes | 248,155 | 0 | 0
Non-cash interest expense on liability related to sale of future royalties | 6,604 | 6,899 | 7,217
Non-deductible officers' compensation | 2,547 | 220 | 184
Change in valuation allowance | (186,124) | 51,981 | 22,210
Stock-based compensation | (20,665) | 528 | 674
Sale of future royalties | (8,236) | 0 | 0
Research credits | (8,038) | (4,543) | (4,529)
Foreign tax deduction | 0 | 0 | 1,773
Other | 0 | (782) | 1,212
Provision for income taxes | $ 616 | $ 876 | $ 506

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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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