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Commitments and Contingencies - Additional Information (Detail) - USD ($) |  |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Jun. 30, 2017 | Jun. 26, 2017 | Dec. 31, 2017 | Jun. 30, 2017 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Aug. 14, 2015
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Purchase commitments related to contract manufacturing, clinical development and certain other items |  |  | $ 16,500,000 |  | $ 16,500,000 |  |  |
Royalty expense |  |  |  |  | 3,100,000 | $ 3,700,000 | $ 2,800,000 |
Indemnification Obligation [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Litigation matters, liabilities |  |  | 0 |  | 0 | 0 |  |
Merger and Acquisition Related Claims [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Obligations under Director and Officer Indemnifications per incident |  |  | 1,800,000 |  | 1,800,000 |  |  |
Securities Related Claims [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Obligations under Director and Officer Indemnifications per incident |  |  | 1,800,000 |  | 1,800,000 |  |  |
Non-Securities Related Claims [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Obligations under Director and Officer Indemnifications per incident |  |  | 500,000 |  | 500,000 |  |  |
Cross-License Agreement [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Total payments due related to license agreement amendment |  | $ 7,000,000 |  |  |  |  |  |
Payment made related to license agreement amendment |  |  | 3,500,000 | $ 3,500,000 |  |  |  |
Litigation matters, prepayment of royalty obligations for future commercial sales | $ 2,300,000 |  |  |  |  |  |  |
Litigation matters, liabilities |  |  |  |  |  | $ 0 |  |
Cross-License Agreement [Member] | Cost of Goods Sold [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Accrued royalties for commercial sales |  |  | 1,400,000 |  | 1,400,000 |  |  |
Cross-License Agreement [Member] | General and Administrative Expense [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Accrued expense related to license agreement amendment |  |  |  |  | 3,300,000 |  |  |
Cross-License Agreement [Member] | Other Current Assets [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Unamortized prepaid royalty |  |  | $ 600,000 |  | $ 600,000 |  |  |
Enzon Litigation [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Damage claim for alleged unpaid licenses |  |  |  |  |  |  |  | $ 1,500,000
Enzon Litigation [Member] | Cross-License Agreement [Member] |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |
Litigation matters, dismissal date |  |  |  |  | Jun. 30, 2017 |  |  |

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