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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands, shares in Millions | 12 Months Ended |
--- | --- | ---
Dec. 31, 2017 USD ($) Customer Reporting_Unit shares | Dec. 31, 2016 USD ($) Customer shares | Dec. 31, 2015 shares | Jan. 01, 2017 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cash and investments in marketable securities | $ 353,220 | $ 389,102 |  |
Senior secured notes | $ 250,000 |  |  |
Senior secured notes, maturity date | Oct. 05, 2020 |  |  |
Number of customers accounted for major accounts receivable | Customer | 4 | 3 |  |
Percentage of accounts receivable customers one | 43.00% | 39.00% |  |
Percentage of accounts receivable customers two | 20.00% | 32.00% |  |
Percentage of accounts receivable customers three | 19.00% | 13.00% |  |
Percentage of accounts receivable customers four | 14.00% |  |  |
Number of reporting unit evaluated for goodwill | Reporting_Unit | 1 |  |  |
Minimum percentage of amount realized upon ultimate settlement | 50.00% |  |  |
ASC 606 [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Estimated adjustment to accumulated deficit accrued royalties | $ 11,000 |  |  |
Adoption of New Accounting Principles [Member] | Other Current Assets [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Impact of reclassification due to adoption of new accounting pronouncement |  |  |  | $ 300
Accumulated Deficit [Member] | Adoption of New Accounting Principles [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Impact of reclassification due to adoption of new accounting pronouncement |  |  |  | $ 200
Federal [Member] | Stock Option Windfall Deductions | Adoption of New Accounting Principles [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Impact of reclassification due to adoption of new accounting pronouncement |  | $ 20,600 |  |
State [Member] | Stock Option Windfall Deductions | Adoption of New Accounting Principles [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Impact of reclassification due to adoption of new accounting pronouncement |  | $ 9,800 |  |
Stock Options and Restricted Stock Units [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Weighted average diluted securities excluded from diluted net loss per share | shares | 20.6 | 19.9 | 21.1 |
Minimum [Member] | ASC 606 [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Estimated adjustment to decrease in accumulated deficit | $ 11,000 |  |  |
Maximum [Member] | ASC 606 [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Estimated adjustment to decrease in accumulated deficit | 13,000 |  |  |
Estimated adjustment to accumulated deficit unamortized portion of upfront payment amounts recognized | $ 2,000 |  |  |
Buildings [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives | 20 years |  |  |
Manufacturing Laboratory and Other Equipment [Member] | Minimum [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives | 3 years |  |  |
Manufacturing Laboratory and Other Equipment [Member] | Maximum [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Property and equipment estimated useful lives | 10 years |  |  |

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