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Property, Plant and Equipment (Tables)
12 Months Ended
Dec. 31, 2017
Property Plant And Equipment [Abstract]  
Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

 

 

 

December 31,

 

 

 

2017

 

 

2016

 

Building and leasehold improvements

 

$

81,444

 

 

$

75,137

 

Laboratory equipment

 

 

31,214

 

 

 

27,424

 

Furniture, fixtures and other equipment

 

 

27,800

 

 

 

26,590

 

Manufacturing equipment

 

 

20,695

 

 

 

44,237

 

Depreciable property, plant and equipment at cost

 

 

161,153

 

 

 

173,388

 

Less: accumulated depreciation and amortization

 

 

(115,090

)

 

 

(111,243

)

Depreciable property, plant and equipment, net

 

 

46,063

 

 

 

62,145

 

Construction-in-progress

 

 

1,400

 

 

 

3,456

 

Property, plant and equipment, net

 

$

47,463

 

 

$

65,601