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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Loss Before Provision for Income Taxes

Loss before provision for income taxes includes the following components (in thousands):

		Year Ended December 31,
		2017				2016				2015
Domestic		$	(97,938	)		$	(155,375	)		$	(81,931	)
Foreign			1,862				2,727				1,260
Loss before provision for income taxes		$	(96,076	)		$	(152,648	)		$	(80,671	)

Provision for Income Taxes

The provision for income taxes consists of the following (in thousands):

		Year Ended December 31,
		2017				2016				2015
Current:
Federal		$	—			$	—			$	—
State			1				(1	)			(1	)
Foreign			580				992				529
Total Current			581				991				528
Deferred:
Federal			—				—				—
State			—				—				—
Foreign			35				(115	)			(22	)
Total Deferred			35				(115	)			(22	)
Provision for income taxes		$	616			$	876			$	506

Income Tax Provision Related to Continuing Operations

Income tax provision related to continuing operations differs from the amount computed by applying the statutory income tax rate of 35% to pretax loss as follows (in thousands):

		Year Ended December 31,
		2017				2016				2015
U.S. federal provision (benefit)
At statutory rate		$	(33,627	)		$	(53,427	)		$	(28,235	)
Tax law changes			248,155				—				—
Non-cash interest expense on liability related to sale of    future royalties			6,604				6,899				7,217
Non-deductible officers' compensation			2,547				220				184
Change in valuation allowance			(186,124	)			51,981				22,210
Stock-based compensation			(20,665	)			528				674
Sale of future royalties			(8,236	)			—				—
Research credits			(8,038	)			(4,543	)			(4,529	)
Foreign tax deduction			—				—				1,773
Other			—				(782	)			1,212
Provision for income taxes		$	616			$	876			$	506

Significant Components of Deferred Tax Assets and Liabilities

We remeasured certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which includes the change in the federal rate to 21%. Significant components of our deferred tax assets for federal and state income taxes are as follows (in thousands):

		December 31,
		2017				2016
Deferred tax assets:
Net operating loss carryforwards		$	364,864			$	508,406
Research and other credits			94,103				74,917
Stock-based compensation			14,552				26,357
Property, plant and equipment			6,848				6,882
Reserves and accruals			5,659				12,269
Capitalized research expenses			5,497				11,587
Deferred revenue			3,796				23,035
Sale of future royalties			—				1,611
Other			1,156				750
Deferred tax assets before valuation allowance			496,475				665,814
Valuation allowance for deferred tax assets			(496,191	)			(665,514	)
Total deferred tax assets			284				300
Total deferred tax liabilities			—				—
Net deferred tax assets		$	284			$	300

Unrecognized Tax Benefits

We have the following activity relating to unrecognized tax benefits (in thousands):

		December 31,
		2017				2016				2015
Beginning balance		$	18,413			$	17,384			$	27,522
Tax positions related to current year
Additions:
Federal			1,206				530				529
State			1,666				499				443
Reductions			—				—				—
Tax positions related to prior year
Additions:
Federal			—				—				—
State			—				—				—
Foreign			—				—				—
Reductions			(802	)			—				(11,110	)
Settlements			—				—				—
Lapses in statute of limitations			—				—				—
Ending balance		$	20,483			$	18,413			$	17,384

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Income loss before provision for income taxes.

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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Tabular disclosure of the change in unrecognized tax benefits, excluding amounts pertaining to examined tax returns.

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-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15A
-URI http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319

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