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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenue:      
Product sales $ 32,688 $ 55,354 $ 40,155
Royalty revenue 33,527 19,542 2,967
Non-cash royalty revenue related to sale of future royalties 30,531 30,158 22,058
License, collaboration and other revenue 210,965 60,382 165,604
Total revenue 307,711 165,436 230,784
Operating costs and expenses:      
Cost of goods sold 30,547 30,215 34,102
Research and development 268,461 203,801 182,787
General and administrative 52,364 44,275 43,266
Impairment of equipment and other costs for terminated program 15,981 0 0
Total operating costs and expenses 367,353 278,291 260,155
Loss from operations (59,642) (112,855) (29,371)
Non-operating income (expense):      
Interest expense (22,085) (22,468) (18,282)
Non-cash interest expense on liability related to sale of future royalties (18,869) (19,712) (20,619)
Loss on extinguishment of debt 0 0 (14,079)
Interest income and other income (expense), net 4,520 2,387 1,680
Total non-operating expense, net (36,434) (39,793) (51,300)
Loss before provision for income taxes (96,076) (152,648) (80,671)
Provision for income taxes 616 876 506
Net loss $ (96,692) $ (153,524) $ (81,177)
Basic and diluted net loss per share $ (0.62) $ (1.10) $ (0.61)
Weighted average shares outstanding used in computing basic and diluted net loss per share 155,953 139,596 132,458