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Property, Plant and Equipment - Property, Plant and Equipment (Detail) - USD ($)
$ in Thousands
Dec. 31, 2017
Dec. 31, 2016
Property, Plant and Equipment [Line Items]    
Depreciable property and equipment at cost $ 161,153 $ 173,388
Less: accumulated depreciation and amortization (115,090) (111,243)
Depreciable property, plant and equipment, net 46,063 62,145
Construction-in-progress 1,400 3,456
Property plant and equipment, net 47,463 65,601
Building and Leasehold Improvements [Member]    
Property, Plant and Equipment [Line Items]    
Depreciable property and equipment at cost 81,444 75,137
Manufacturing Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Depreciable property and equipment at cost 20,695 44,237
Laboratory Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Depreciable property and equipment at cost 31,214 27,424
Furniture, Fixtures and Other Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Depreciable property and equipment at cost $ 27,800 $ 26,590