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Liability Related to the Sale of Future Royalties - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended 70 Months Ended
Feb. 24, 2012
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2017
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2017
Liability Related to the Sale of Future Royalties [Line Items]                
Royalty agreement contingent payment description         As a result of worldwide net sales of MIRCERA® for the 12 month periods ended December 31, 2013 and 2012 not reaching certain minimum thresholds.      
Non-cash royalty revenue related to sale of future royalties         $ 30,531 $ 30,158 $ 22,058 $ 137,531
Non-cash interest expense on liability related to sale of future royalties         $ 18,869 $ 19,712 $ 20,619 $ 120,453
Annual interest rate       17.60%       17.00%
Prospective interest rate       21.00%        
Purchase and Sale Agreement with RPI [Member]                
Liability Related to the Sale of Future Royalties [Line Items]                
Proceeds from sale of royalty rights $ 124,000              
Transaction costs related to sale of potential future royalties $ 4,400              
Payment made for milestone not achieved year two   $ 7,000            
Payment made for milestone not achieved year one     $ 3,000