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Commitments and Contingencies - Additional Information (Detail) - USD ($)
 1 Months Ended 12 Months Ended
Jun. 30, 2017
Jun. 26, 2017
Dec. 31, 2017
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Aug. 14, 2015
Loss Contingencies [Line Items]                
Purchase commitments related to contract manufacturing, clinical development and certain other items     $ 16,500,000   $ 16,500,000      
Royalty expense         3,100,000 $ 3,700,000 $ 2,800,000  
Indemnification Obligation [Member]                
Loss Contingencies [Line Items]                
Litigation matters, liabilities     0   0 0    
Merger and Acquisition Related Claims [Member]                
Loss Contingencies [Line Items]                
Obligations under Director and Officer Indemnifications per incident     1,800,000   1,800,000      
Securities Related Claims [Member]                
Loss Contingencies [Line Items]                
Obligations under Director and Officer Indemnifications per incident     1,800,000   1,800,000      
Non-Securities Related Claims [Member]                
Loss Contingencies [Line Items]                
Obligations under Director and Officer Indemnifications per incident     500,000   500,000      
Cross-License Agreement [Member]                
Loss Contingencies [Line Items]                
Total payments due related to license agreement amendment   $ 7,000,000            
Payment made related to license agreement amendment     3,500,000 $ 3,500,000        
Litigation matters, prepayment of royalty obligations for future commercial sales $ 2,300,000              
Litigation matters, liabilities           $ 0    
Cross-License Agreement [Member] | Cost of Goods Sold [Member]                
Loss Contingencies [Line Items]                
Accrued royalties for commercial sales     1,400,000   1,400,000      
Cross-License Agreement [Member] | General and Administrative Expense [Member]                
Loss Contingencies [Line Items]                
Accrued expense related to license agreement amendment         3,300,000      
Cross-License Agreement [Member] | Other Current Assets [Member]                
Loss Contingencies [Line Items]                
Unamortized prepaid royalty     $ 600,000   $ 600,000      
Enzon Litigation [Member]                
Loss Contingencies [Line Items]                
Damage claim for alleged unpaid licenses               $ 1,500,000
Enzon Litigation [Member] | Cross-License Agreement [Member]                
Loss Contingencies [Line Items]                
Litigation matters, dismissal date         Jun. 30, 2017